Computational Modeling of Cell Mechanics Based on Experimental Modulation of Cytoskeletal Components
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Vysoké učení technické v Brně / Fakulta strojního inženýrství
Contest type
VS - Public tender
Contract ID
26-20714S
Alternative language
Project name in Czech
Computational Modeling of Cell Mechanics Based on Experimental Modulation of Cytoskeletal Components
Annotation in Czech
Biomechanical models tied to experiments represent decisive tools in investigating processes in living organs, tissues and cells. Cellular mechanical properties represent an important indicator for distinguishing between healthy and cancer cells, which can be exploited not only in research but also in cancer diagnostics and possibly therapy. The experimental application of mechanical stimuli for estimating these properties can be advantageously complemented by computational models to evaluate non-measurable quantities, especially due to the capability of structure-based Finite Element models to analyze the role of individual components in the cell mechanical responses. Their comprehensive validation is ensured by tailored experiments. Herein, the existing structure-based bendotensegrity Finite Element model will be enhanced to capture realistic cell geometry and structure, cellular adhesion and changes in actin fiber prestress. These features are deemed essential in the observed variances in mechanical properties between healthy and cancer cells and important in cancer metastasis.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
20601 - Medical engineering
OECD FORD - secondary branch
20301 - Mechanical engineering
OECD FORD - another secondary branch
10601 - Cell biology
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EA - Morphology and cytology<br>FS - Medical facilities, apparatus and equipment<br>JR - Other machinery industry<br>JT - Propulsion, engines and fuels
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
May 19, 2026
Finance
Total approved costs
8,579 thou. CZK
Public financial support
8,483 thou. CZK
Other public sources
96 thou. CZK
Non public and foreign sources
0 thou. CZK