The Dynamic Interplay of Germ Cells and Somatic Cells Lineages in Gonadal Tissue Regeneration in Fish
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Jihočeská univerzita v Českých Budějovicích / Fakulta rybářství a ochrany vod
Contest type
VS - Public tender
Contract ID
26-21447S
Alternative language
Project name in Czech
The Dynamic Interplay of Germ Cells and Somatic Cells Lineages in Gonadal Tissue Regeneration in Fish
Annotation in Czech
Among vertebrates, fish stand out as excellent models to study regeneration. Our preliminary data demonstrate that the gonad can fully regenerate after an injury. This opens an exciting avenue towards tackling fertility issues originating from traumas or pathological condition causing permanent gonadal tissue loss due to inability to regenerate. First, it is necessary to characterize the regenerative process and its main components. It remains unclear whether regeneration recapitulates normal gonadal development or whether injury triggers alternative mechanisms, such as germ cell dedifferentiation or the activation of somatic gonadal cells. Partial gonadectomy will be used to induce regeneration in zebrafish and killifish followed by transcriptomics, loss-of-function experiments, and cell ablation, allowing us to dissect the processes facilitating successful regeneration. The goal is to identify pathways regulating regeneration after an injury. Ultimately, we aim to provide novel insights into gonadal biology, with potential implications for regenerative and fertility science.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10604 - Reproductive biology (medical aspects to be 3)
OECD FORD - secondary branch
10605 - Developmental biology
OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EB - Genetics and molecular biology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Apr 30, 2026
Finance
Total approved costs
12,081 thou. CZK
Public financial support
12,038 thou. CZK
Other public sources
43 thou. CZK
Non public and foreign sources
0 thou. CZK