Molecular capsules based on bridged bambusurils

Project name in Czech
Molecular capsules based on bridged bambusurils
Annotation in Czech
Bambusurils are macrocycles with a high binding affinity for inorganic anions. Previous studies have shown that while bambusuril binding affinity can be enhanced by introducing electron-withdrawing substituents, their selectivity can be tuned by attaching sterically demanding substituents that rigidify the macrocyclic structure. In this project, we propose the synthesis of bambusuril derivatives with a capsule-like shape. In these capsules, glycoluril units on the opposite portals are connected via molecular linkers. These bridges can influence the macrocycle’s flexibility and, consequently, its anion-binding selectivity. Various synthetic approaches for the proposed capsules will be explored, and their subsequent modifications will be studied. The supramolecular host-guest interactions between the prepared rigid capsules and anions in different solvents will be investigated using various techniques, including nuclear magnetic resonance spectroscopy and isothermal titration calorimetry.

R&D category
ZV - Basic research
OECD FORD - main branch
10401 - Organic chemistry
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
CC - Organic chemistry

Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Apr 29, 2026

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