When Auto- and Allopolyploidy Meet: Fate of Parental Genomes and Meiotic Stabilization in Asexual Hybrids
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-22822S
Alternative language
Project name in Czech
When Auto- and Allopolyploidy Meet: Fate of Parental Genomes and Meiotic Stabilization in Asexual Hybrids
Annotation in Czech
Genome duplication is important in metazoan evolution, yet neopolyploids must overcome major challenges, such as initial rarity among diploid ancestors, meiotic instability due to multiple homologous chromosomes, and disrupted regulatory networks in allopolyploids. Although mechanisms facilitating neopolyploid stabilization are actively studied, they remain poorly understood. A promising pathway to polyploidy may involve interspecific hybridization, which can trigger aberrant gametogenetic programs—often leading to premeiotic endoreplication (PMER) in oogonia and subsequent production of unreduced gametes. Hybrids with PMER thus serve as unique models integrating both auto- and allopolyploid genomic features within a single nucleus. We will investigate Cobitis hybrids, where clonal lineages with PMER have repeatedly arisen from diverse parental species combinations. This system uniquely enables testing how polyploidization and genome divergence—whether inherited or evolved—affect meiotic stability in hybrid/polyploid contexts.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
OECD FORD - secondary branch
10603 - Genetics and heredity (medical genetics to be 3)
OECD FORD - another secondary branch
10604 - Reproductive biology (medical aspects to be 3)
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EA - Morphology and cytology<br>EB - Genetics and molecular biology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Jul 27, 2026
Finance
Total approved costs
13,657 thou. CZK
Public financial support
13,493 thou. CZK
Other public sources
164 thou. CZK
Non public and foreign sources
0 thou. CZK