Reconstitution of mammalian centrosome after fertilisation
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Masarykova univerzita / Lékařská fakulta
Contest type
VS - Public tender
Contract ID
26-23780S
Alternative language
Project name in Czech
Reconstitution of mammalian centrosome after fertilisation
Annotation in Czech
Fertilisation in mammals involves the integration of parental genomes and the reconstitution of the centrosome, a key microtubule-organising centre essential for accurate cell division. Unlike rodents, human and bovine sperm contribute centrioles to the zygote, enabling centrosome formation. However, the mechanisms driving the incorporation and function of sperm-derived centrioles remain poorly understood. This project will use advanced live-cell imaging in bovine embryos to investigate how sperm centrioles transform into functional zygotic centrosomes, contribute to spindle assembly, and influence early cell fate. By combining high-resolution microscopy, molecular perturbations, and lineage tracing, we aim to uncover how centrosome dynamics impact embryo viability and shed light on the origins of developmental failure in humans.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10604 - Reproductive biology (medical aspects to be 3)
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EB - Genetics and molecular biology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
May 4, 2026
Finance
Total approved costs
7,126 thou. CZK
Public financial support
7,126 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK