Systems biology of streptomyces germination
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
Standardní projekty 14 (SGA02011GA-ST)
Main participants
Mikrobiologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
P302-11-0229
Alternative language
Project name in Czech
Systémová biologie germinace streptomycet
Annotation in Czech
Cílem projektu je analýza procesu germinace bakterie Streptomyces coelicolor na systémové úrovni. Proces germinace, začínající v dormantních sporách, bude analyzován pomocí odběru a kvantitativního měření proteinových a mRNA vzorků v krátkých časových intervalech. Geny exprimované během specifických fází germinace budou identifikovány a mapovány na existující metabolické dráhy. Analýza časových řad exprese genů a proteinů identifikuje klíčové regulátory, pro které budou identifikovány genetické regulační sítě. Struktura metabolických a genetických sítí bude verifikována mutagenezí a kvantitativním měřením genové exprese. Výsledkem budou metabolické a genetické sítě aktivované během procesu germinace.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
EE - Microbiology, virology
CEP - secondary branch
EI - Biotechnology and bionics
CEP - another secondary branch
EB - Genetics and molecular biology
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10606 - Microbiology<br>10607 - Virology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>20801 - Environmental biotechnology<br>20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management<br>20803 - Environmental biotechnology related ethics<br>20901 - Industrial biotechnology<br>20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation<br>20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials<br>30101 - Human genetics<br>30401 - Health-related biotechnology<br>30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)<br>30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])<br>30404 - Biomaterials (as related to medical implants, devices, sensors)<br>30405 - Medical biotechnology related ethics<br>40401 - Agricultural biotechnology and food biotechnology<br>40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming<br>40403 - Agricultural biotechnology related ethics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
The final report summarizes results obtained during five year grant that was focused on characterization of mechanism of germination of S. coelicolor. The main goals of the project were achieved and the obtained experimental results were published in 6 articles in international scientific journals. The cumulative IF of published papers is over 33 and an additional manuscript was presented.
Solution timeline
Realization period - beginning
Jan 1, 2011
Realization period - end
Dec 31, 2015
Project status
U - Finished project
Latest support payment
Mar 26, 2015
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP16-GA0-GA-U/01:1
Data delivery date
Sep 25, 2017
Finance
Total approved costs
7,816 thou. CZK
Public financial support
7,816 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK