Electrical Stimulated 3D Scaffold for Bone Regeneration (RESBONREG)
Public support
Provider
Czech Science Foundation
Programme
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Call for proposals
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Main participants
Ústav experimentální medicíny AV ČR, v. v. i.
Contest type
M2 - International cooperation
Contract ID
26-23142L
Alternative language
Project name in Czech
Electrical Stimulated 3D Scaffold for Bone Regeneration (RESBONREG)
Annotation in Czech
The project aims to develop new types of multifunctional hybrid electrospun scaffolds for bone regeneration. The hybrid nanofibers exhibit bioinspired architectures, utilizing a combination of responsive, biodegradable polymer matrices that incorporate a variety of nanostructures. The hybrid scaffold possesses characteristic mechanical stability and facilitates the application of tailored electric fields to induce unique osteoinductive properties in combination with controlled release of pro-osteogenic molecules with antimicrobial properties. Furthermore, external electric stimuli applied to the reconfigurable scaffold results in improved biological performance of the bone-healing process. The project will unravel the mechanism of activation/inhibition of osteoclastogenesis, and the angiogenesis in cocultures under different types of electric stimulation. Through biocompatibility of the hybrid scaffold but also due to its collective chemical, mechanical and electrical properties the scaffold will enable the formation of bone constructs with faster and improved quality.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EI - Biotechnology and bionics
Solution timeline
Realization period - beginning
Apr 1, 2026
Realization period - end
Dec 31, 2029
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GF-R
Data delivery date
May 26, 2026
Finance
Total approved costs
5,857 thou. CZK
Public financial support
5,857 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK