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LH12164

Production of Dendrobium candidum biomass in vitro and study its biological activity

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    KONTAKT II

  • Call for proposals

    KONTAKT II 2 (SMSM2012LH2)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    MSMT-7026/2012-36

Alternative language

  • Project name in Czech

    In vitro produkce biomasy Dendrobium candidum a studium její biologické aktivity

  • Annotation in Czech

    Cíle projektu jsou následující: a) vypěstovat kalusovou a supsenzní kulturu Dendrobium candidum b) u vyprodukované biomasy ověřit protizánětlivou (inhibici cyklooxygenázy-1 a -2 a 5-lipoxygenázy) a antioxidační aktivitu (DPPH a ORAC metoda) c) identifikovat látky které jsou produkovány kalusovými nebo suspenzními kulturami d) ověřit možnosti zvýšení produkce protizánětlivých látek a antioxidantů v kalusových nebo suspenzních kulturách e) vznik vědecké spolupráce a výměny zkušeností mezi pracovišti ČLR aČR Tento projekt představuje, vzhledem ke své omezené délce, jen úvodní krok další spolupráce v této oblasti.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    EI - Biotechnology and bionics

  • CEP - secondary branch

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    20801 - Environmental biotechnology<br>20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management<br>20803 - Environmental biotechnology related ethics<br>20901 - Industrial biotechnology<br>20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation<br>20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials<br>30401 - Health-related biotechnology<br>30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)<br>30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])<br>30404 - Biomaterials (as related to medical implants, devices, sensors)<br>30405 - Medical biotechnology related ethics<br>40401 - Agricultural biotechnology and food biotechnology<br>40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming<br>40403 - Agricultural biotechnology related ethics

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    For one of tested stilbenes ? pinosltibene - strong cyklooxygenase-2 (COX-2) a cyklooxygenase-1 (COX-1) with IC50 values lower than reference inhibitors ibuprofen and indomethacin were recorded. Only pterostilben a oxyresveratrol were capable to inhibitcatalytic activity of 5-LOX with mild activity.

Solution timeline

  • Realization period - beginning

    Mar 1, 2012

  • Realization period - end

    Dec 31, 2013

  • Project status

    U - Finished project

  • Latest support payment

    Feb 27, 2013

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP14-MSM-LH-U/01:1

  • Data delivery date

    Jun 30, 2014

Finance

  • Total approved costs

    1,440 thou. CZK

  • Public financial support

    1,440 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK