Structure and Function of Mitochodrial Secretins
Public support
Provider
Ministry of Education, Youth and Sports
Programme
KONTAKT II
Call for proposals
KONTAKT II 5 (SMSM2015LH5)
Main participants
Univerzita Karlova / Přírodovědecká fakulta
Contest type
VS - Public tender
Contract ID
MSMT-32267/2015-1
Alternative language
Project name in Czech
Název projektu Struktura a funkce mitochondriálního sekretinu.
Annotation in Czech
(i) Objasnit mechanismus importu sekretinu a skládání sekretinového komplexu ve vnější mitochondriální membráně. (ii) Vyhledat proteinové partnery mitochondriálního sekretinu. (iii) Charakterizovat vlastnosti mitochondriálního sekretinového póru pomocí elektrofyziologie. (iv) Vykrystalizovat a pokusit se stanovit krystalovou strukturu proteinu.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
EB - Genetics and molecular biology
CEP - secondary branch
—
CEP - another secondary branch
—
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
In this project, we have identified unique secretion pathway occurring in mitochondria of several eukaryotic lineages. It likely represents the remainder of the original bacterial pathway, which was retained in these mitochondria for so far unknown reasons. The presence of the pathway is of special interest becauseof the nature of the interaction between mitochondria and the rest of the cell during the creation of this crucuial organelle of the eukaryotic cell.
Solution timeline
Realization period - beginning
Oct 1, 2015
Realization period - end
Dec 31, 2017
Project status
U - Finished project
Latest support payment
Mar 2, 2017
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP18-MSM-LH-U/01:1
Data delivery date
Jun 7, 2018
Finance
Total approved costs
1,991 thou. CZK
Public financial support
1,991 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK