Theoretical investigation of RNA structure, dynamics and function and their relationship.
Public support
Provider
Ministry of Education, Youth and Sports
Programme
KONTAKT
Call for proposals
KONTAKT 7 (SMSM2009ME4)
Main participants
—
Contest type
VS - Public tender
Contract ID
2060/2011-320
Alternative language
Project name in Czech
Teoretické studium struktury, dynamiky a funkce RNA a jejich vzájemných vztahů
Annotation in Czech
(1) Získání nových poznatků o struktuře, dynamice a funkci RNA molekul pomocí molekulového modelování. (2) Charakterizace vazebného místa v RNA aptamerech, např. tryptophan aptameru. Design a příprava nových plně funkčních aptamerů.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
EB - Genetics and molecular biology
CEP - secondary branch
CF - Physical chemistry and theoretical chemistry
CEP - another secondary branch
BO - Biophysics
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10403 - Physical chemistry<br>10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>10610 - Biophysics<br>30101 - Human genetics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
In 2012, we continued to study the RNA aptamers. Namely, we performed molecular modeling of the TRP and HIS aptamers. The predicted ligand:aptamer complex structures and calculated binding affinities were then compared to experimental results. We also started the molecular modeling investigation of the hammerhead ribozyme. Results of this project were published in RNA and at conferencies.
Solution timeline
Realization period - beginning
Apr 1, 2009
Realization period - end
Dec 31, 2012
Project status
U - Finished project
Latest support payment
Feb 23, 2012
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP13-MSM-ME-U/01:1
Data delivery date
Jun 28, 2013
Finance
Total approved costs
1,660 thou. CZK
Public financial support
1,660 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK