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Role of glucocorticoid hormones in the Aryl hydrocarbon receptor cellular signalling in human hepatocytes

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    KONTAKT

  • Call for proposals

    KONTAKT 6 (SMSM2008ME3)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    7682/2010-32

Alternative language

  • Project name in Czech

    Úloha glukokortikoidních hormonů v buněčné signalizaci aryl uhlovodíkovým receptorem v lidských hepatocytech

  • Annotation in Czech

    Cílem projektu je studium molekulárních mechanismů interakce mezi signálními drahami glukokortikoidního receptoru a receptoru pro aromatické uhlovodíky (AhR) v primárních kulturách lidských hepatocytů a nádorových buněčných liniích.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    FR - Pharmacology and apothecary chemistry

  • CEP - secondary branch

    CE - Biochemistry

  • CEP - another secondary branch

    EB - Genetics and molecular biology

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30104 - Pharmacology and pharmacy

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    The outcome of the project is an elucidation and understanding molecular mechanisms of mutual interactions between glucocorticoid receptor and aryl hydrocarbon receptor signaling pathways in primary cultures of human hepatocytes.

Solution timeline

  • Realization period - beginning

    Jan 1, 2009

  • Realization period - end

    Dec 31, 2010

  • Project status

    U - Finished project

  • Latest support payment

    Apr 15, 2010

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP11-MSM-ME-U/01:1

  • Data delivery date

    Jun 30, 2011

Finance

  • Total approved costs

    124 thou. CZK

  • Public financial support

    124 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK