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NR9138

Inhibitors of Bacterial RNA Polymerase Based on Nucleotide Analogues

Public support

  • Provider

    Ministry of Health

  • Programme

    Branch programm of research of the Ministry of Health

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví 4 (SMZ02007NR)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NR9138-3/2007

Alternative language

  • Project name in Czech

    Inhibitory bakteriální RNA polymerázy založené na analozích nukleotidů

  • Annotation in Czech

    Navrhujeme vyvinout nové inhibitory bakteriální RNA polymerázy založené na analozích nukleotidů a zacílené do aktivního místa enzymu. Budou použity techniky z molekulární biologie, organické syntézy, 3D modelování, a vysokokapacitní testování inhibitorů.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    EE - Microbiology, virology

  • CEP - secondary branch

    FN - Epidemiology, infection diseases and clinical immunology

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10606 - Microbiology<br>10607 - Virology<br>30302 - Epidemiology<br>30303 - Infectious Diseases

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Novel inhibitors of bacterial RNA polymerase based on nucleotide analogues have been prepared. New approach to synthesis of nucleotide analogues. Defined structure of delta subunit of bacterial RNA polymerase.

Solution timeline

  • Realization period - beginning

    Jan 1, 2007

  • Realization period - end

    Dec 31, 2009

  • Project status

    U - Finished project

  • Latest support payment

    Dec 18, 2009

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP10-MZ0-NR-U/03:3

  • Data delivery date

    Apr 27, 2011

Finance

  • Total approved costs

    9,025 thou. CZK

  • Public financial support

    8,481 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    544 thou. CZK