Changes in the microbiome composition as a risk factor in the development of psoriasis
Project goals
Affecting 2-3% of population, psoriasis is a chronic, autoimmune skin disease that involves dysregulated interplay between immune cells, keratinocytes and environmental triggers. We hypothesize that skin microbiome composition is the crucial aspect for psoriasis induction and perpetuation. Our main goal is to find new markers associated with psoriasis that could be included in preventive medical care and screening. We will search for bacterial species, which contribute to the disease or which could be used in the secondary prevention and which has not been characterized yet. Our next goal is to find out the alterations in microbiome in skin affected by psoriasis and in unaffected areas in patients after local and systemic treatment. Moreover, we will study intestinal barrier disruption as possible cause of systemic low-grade inflammation in psoriasis. Elucidation of the host-microbe interactions could help us to better understand the pathogenesis, discover the risk factors and provide new approaches in the prevention of psoriasis.
Keywords
psoriázamikrobiomlokální a systémová léčbaantibiotikastřevní propustnostsekundární prevencepsoriasismicrobiomelocal and systemic treatmentantibioticintestinal permeabilitysecondary prevention
Public support
Provider
Ministry of Health
Programme
Programme to support medical applied research in 2015 to 2022
Call for proposals
Zdravotnický AV 1 (SMZ0201501)
Main participants
Fakultní nemocnice Bulovka
Contest type
VS - Public tender
Contract ID
15-30782A
Alternative language
Project name in Czech
Změny ve složení mikrobiomu jako rizikový faktor v rozvoji psoriázy
Annotation in Czech
Psoriáza je chronické autoimunitní kožní onemocnění neznámé etiologie, které je spojeno s dysregulací buněk imunitního systému a hyperproliferací keratinocytů. Psoriázou jsou postižena 2-3 % populace a na jejím vzniku se výrazně podílí faktory životního prostředí. Předpokládáme, že složení kožního mikrobiomu je jedním z důležitých faktorů pro vznik i progresi psoriázy. Naším hlavním cílem je nalézt nové biomarkery psoriázy, které by bylo možné využít v preventivní medicíně a skríningu. Budeme hledat specifické bakterie, které psoriázu přímo ovlivňují nebo by mohly být přímo využity v sekundarní prevenci a dosud nebyly popsány. Kromě toho budeme sledovat, jak změny ve složení kožní mikrobioty u léčených a neléčených pacientů s psoriázou ovlivňují patogenezi tohoto onemocnění. Dále budeme sledovat, zda je porušení střevní bariéry příčinou chronického systémového zánětu u pacientů s psoriázou. Pochopení vztahu mezi mikrobem a hostitelem nám umožní lépe porozumět patogenezi psoriázy, odhalit rizikové faktory a vyvinout nové preventivní postupy.
Scientific branches
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
The results of this fruitful collaboration were already published in 4 papers, moreover 3 papers were submitted and are under the review (to this date 30.1.2019) in impacted journals. All obtained and published data have substantial impact on the future biomedical research in the dermatology field. Students formed important part of the research team: 3 PhD students in IMIC were partly involved in the project. While none of themdefended their thesis during its duration, results obtained in this project will become an integral part of their PhD dissertations. We consider this project to be exceptionally successful. Detailed descriptions of the results were presented in annual reports and the main achievements of the project will be highlighted here. The main scope of our project was successfully fulfilled. We found new bacterial and fungal markers that are associated with psoriasis (Stehlikova et al. submitted manuscript/under review). We analyzed microbiota in skin affected by psoriasi
Solution timeline
Realization period - beginning
May 1, 2015
Realization period - end
Dec 31, 2018
Project status
U - Finished project
Latest support payment
Jun 28, 2018
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP19-MZ0-NV-U/02:1
Data delivery date
Sep 16, 2019
Finance
Total approved costs
6,426 thou. CZK
Public financial support
6,426 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
6 426 CZK thou.
Public support
6 426 CZK thou.
100%
Provider
Ministry of Health
CEP
FO - Dermatology and venereology
Solution period
01. 05. 2015 - 31. 12. 2018