Novel inhibitors of acetylcholinesterase as prophylaxis of nerve agent poisonings
Public support
Provider
Ministry of Defence
Programme
Development - the development of attained operational capabilities of the Czech Armed Forces
Call for proposals
Rozvoj AČR 1 (SMO02008PR980)
Main participants
—
Contest type
VS - Public tender
Contract ID
0801 8 8080 R
Alternative language
Project name in Czech
INHIBITOR - Výzkum nových inhibitorů acetylcholinesterasy jako profylaxe intoxikací nervově-paralytickými látkami
Annotation in Czech
Projekt se zabývá hledáním vhodného reverzibilního inhibitoru AChE in vitro jako náhrady profylaktika pyridostigminu. Za tímto účelem bude připraveno 100 reverzibilních inhibitorů AChE, které budou testovány in vitro a porovnány s profylaktiky zavedenýmiv Armádě České Republiky. Na základě výsledků vztahů mezi strukturou a aktivitou bude vybrán a doporučen reverzibilní inhibitor AChE vhodný pro in vivo testování.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FP - Other medical fields
CEP - secondary branch
KA - Militarism
CEP - another secondary branch
—
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
21100 - Other engineering and technologies<br>30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Project Inhibitor was focused on synthesis, in vitro evaluation a structure activity relationship of novel cholinesterase inhibitors. Approximately 100 novel molecules were prepared and their inibitory ability was tested on human acetylcholinesterase andbutyrylcholinesterase, while inhibitory results of some novel compounds were comparable to used standards.
Solution timeline
Realization period - beginning
Nov 1, 2008
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Feb 28, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-MO0-OV-U/01:1
Data delivery date
Jul 2, 2012
Finance
Total approved costs
1,805 thou. CZK
Public financial support
1,265 thou. CZK
Other public sources
540 thou. CZK
Non public and foreign sources
0 thou. CZK