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Novel inhibitors of acetylcholinesterase as prophylaxis of nerve agent poisonings

Public support

  • Provider

    Ministry of Defence

  • Programme

    Development - the development of attained operational capabilities of the Czech Armed Forces

  • Call for proposals

    Rozvoj AČR 1 (SMO02008PR980)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    0801 8 8080 R

Alternative language

  • Project name in Czech

    INHIBITOR - Výzkum nových inhibitorů acetylcholinesterasy jako profylaxe intoxikací nervově-paralytickými látkami

  • Annotation in Czech

    Projekt se zabývá hledáním vhodného reverzibilního inhibitoru AChE in vitro jako náhrady profylaktika pyridostigminu. Za tímto účelem bude připraveno 100 reverzibilních inhibitorů AChE, které budou testovány in vitro a porovnány s profylaktiky zavedenýmiv Armádě České Republiky. Na základě výsledků vztahů mezi strukturou a aktivitou bude vybrán a doporučen reverzibilní inhibitor AChE vhodný pro in vivo testování.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    FP - Other medical fields

  • CEP - secondary branch

    KA - Militarism

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    21100 - Other engineering and technologies<br>30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    Project Inhibitor was focused on synthesis, in vitro evaluation a structure activity relationship of novel cholinesterase inhibitors. Approximately 100 novel molecules were prepared and their inibitory ability was tested on human acetylcholinesterase andbutyrylcholinesterase, while inhibitory results of some novel compounds were comparable to used standards.

Solution timeline

  • Realization period - beginning

    Nov 1, 2008

  • Realization period - end

    Dec 31, 2011

  • Project status

    U - Finished project

  • Latest support payment

    Feb 28, 2011

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP12-MO0-OV-U/01:1

  • Data delivery date

    Jul 2, 2012

Finance

  • Total approved costs

    1,805 thou. CZK

  • Public financial support

    1,265 thou. CZK

  • Other public sources

    540 thou. CZK

  • Non public and foreign sources

    0 thou. CZK