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14 547 (0,115s) •

Project

High throughput bacterial genome assembly and annotation techniques using genomic signal processing (GA17-01821S)

The project is focused on computational whole-genome analysis of bacteria using digital signal processing methods (DSP). As first, a new algorithm for genome assembly in signal representation. The algorith...

IN - Informatika

  • 2017 - 2021
    • •
  • 5 555 tis. Kč
    • •
  • 5 483 tis. Kč
    • •
  • GA ČR
Project

Identification of cis-acting signal and trans-acting proteins involved in DNA encapsidation and viral assembly of mouse polyomavirus. (GPP302/10/P118)

The project focuses on the mouse polyomavirus virion assembly process. The aim of this proposal is to identify cis-acting DNA signal sequence for encapsidation of viral genome as well as trans-acting protein/s involved in v...

EE - Mikrobiologie, virologie

  • 2010 - 2014
    • •
  • 2 298 tis. Kč
    • •
  • 2 298 tis. Kč
    • •
  • GA ČR
Project

Genomic integrity and instability mechanisms in the pathogenesis and potential personalized targeted treatment of prostate cancer. (NS10282)

Genomic integrity and instability mechanisms in the pathogenesis and potential of this project is analysis of cell cycle checkpoints and genome integrity maintenance stem cells in these processes. We will use cell culture a...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 5 158 tis. Kč
    • •
  • 5 148 tis. Kč
    • •
  • MZ
Project

Real-time determination of infection threats from raw nanopore signals using machine learning techniques (GA23-05845S)

proposed approach utilizes real-time run access to process raw nanopore data, allowing...

Microbiology

  • 2023 - 2025
    • •
  • 9 491 tis. Kč
    • •
  • 9 491 tis. Kč
    • •
  • GA ČR
Project

Retrotransposon colonizing only recombining part of genome of dioecious plants (GPP501/10/P483)

Large portions of eukaryotic genomes consist of transposable elements (TEs). Chromosomal distribution and abundance of various families of TEs in genomes is affected of the repetitive sequences in S. latifolia genome, gypsy...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 1 897 tis. Kč
    • •
  • 1 897 tis. Kč
    • •
  • GA ČR
Project

Hemicatenated DNA loops their occurence in humen genome and recognition by tumor suppressor protein p53 (IAA400040702)

Results of mapping of human genome provided evidence that DNA sequences encoding proteins represented only ~3% of human genome. Alternative DNA structures are of particular interest as potential signals to mark important si...

CE - Biochemie

  • 2007 - 2010
    • •
  • 2 428 tis. Kč
    • •
  • 2 428 tis. Kč
    • •
  • AV ČR
Project

Signaling pathways regulating genome integrity during oocyte-to-embryo transition (GA25-18241S)

development jeopardizes genomic stability. The formation of aneuploid embryos diminishes microscopy, RNA sequencing, and proteomics to explore the role of signaling pathways phase required to accumulate zygotic genome acti...

Cell biology

  • 2025 - 2027
    • •
  • 8 121 tis. Kč
    • •
  • 8 121 tis. Kč
    • •
  • GA ČR
Project

The Wnt signaling network – novel components and regulatory mechanisms (GA15-25100S)

The Wnt signaling pathway is a complex molecular network that regulates diverse processes during embryogenesis and in adult tissues. Dysfunction of Wnt signaling-genome scale to identify genes regulating the Wnt

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 7 350 tis. Kč
    • •
  • 7 350 tis. Kč
    • •
  • GA ČR
Project

Comprehensive CRISPR-based functional analysis of deubiquitinases (DUBs) in cellular transformation for the discovery of new targets in cancer therapy (GA21-21413S)

Protein modifications by ubiquitin (Ub) govern vital cellular processes, and signaling. Aberrant or deregulated ubiquitination leads to cellular transformation the ubiquitination processes mediated by Ub ligases. However, t...

Biochemistry and molecular biology

  • 2021 - 2024
    • •
  • 10 011 tis. Kč
    • •
  • 10 011 tis. Kč
    • •
  • GA ČR
Project

Selection of genomic defects in chronic lymphocytic leukemia and their impact on disease outcome (NV15-31834A)

In chronic lymphocytic leukemia (CLL), the absence of primary genomic defect of complex genomic changes since they typically represent cases with more aggressive to uncover genetic defects contributing to the development of geno...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 912 tis. Kč
    • •
  • 9 912 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 14 547