All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

8 (0,137s) •

Project

Optimization of cystic fibrosis patient-derived cellular models to asses restoration of CFTR function in patients with cystic fibrosis (NU23-07-00079)

The discovery of modulators that target cystic fibrosis transmembrane conductance regulator (CFTR) protein has opened the era of cystic fibrosis (CF) curative treatment. Although this therapy is termed mutation specific, strikingly a level of therape...

Paediatrics

  • 2023 - 2026
    • •
  • 15 195 tis. Kč
    • •
  • 15 195 tis. Kč
    • •
  • MZ
Project

Intestinal organoids as an in-vitro model for predicting the response to therapies correcting molecular defects in cystic fibrosis (NU20-07-00049)

The discovery of modulators that target cystic fibrosis transmembrane conductance regulator (CFTR) protein has opened the era of CF curative treatment. Although this therapy is termed mutation specific, strikingly a level of therapeutic response diff...

Paediatrics

  • 2020 - 2023
    • •
  • 11 461 tis. Kč
    • •
  • 11 461 tis. Kč
    • •
  • MZ
Project

Integration of novel RNA-nanotherapeutics in patient-derived breast cancer organoids (NU23J-08-00035)

RNA-based therapy is revolutionizing the healthcare strategy worldwide. The flexible design of RNA molecules combined with the scalability and tunability of lipid nanoparticles, make RNA-nanotherapeutics a promising candidate for the establishment of...

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 6 894 tis. Kč
    • •
  • 6 894 tis. Kč
    • •
  • MZ
Project

Unraveling Molecular Mechanisms of Glioblastoma Treatment Resistance and Recurrence Insights from a 3D GLICO Model (NW24-08-00157)

Glioblastoma IDH-wildtype WHO G4 (GB) is a primary malignant brain tumor characterized by its resistance to therapy and poor prognosis. Despite advances in surgical techniques, targeted radiotherapy, and chemotherapeutics, GB remains incurable with l...

Cell biology

  • 2024 - 2027
    • •
  • 13 773 tis. Kč
    • •
  • 13 773 tis. Kč
    • •
  • MZ
Project

Brain organoids for target detection for precision treatment of schizophrenia (NW24-04-00158)

The project takes advantage of the induced pluripotent stem cell technology to derive neurons and brain organoids from donors with treatment resistant schizophrenia (TRS). TRS subjects fail to respond to standard antidopaminergic drugs, but respond t...

Psychiatry

  • 2024 - 2027
    • •
  • 13 064 tis. Kč
    • •
  • 13 064 tis. Kč
    • •
  • MZ
Project

Application of retinal cells and organoids in functional diagnostics and treatment of vision loss in Bardet-Biedl syndrome (NU22-07-00380)

Inherited retinal diseases are a genetically heterogeneous group of rare eye disorders with a progressive manifestation causing vision loss, affecting approximately one in 2,000 individuals worldwide. An increasing number of genes have been associate...

Ophthalmology

  • 2022 - 2025
    • •
  • 10 915 tis. Kč
    • •
  • 10 915 tis. Kč
    • •
  • MZ
Project

Pathogen-induced senescence as the initiation trigger for the onset of Alzheimer’s disease (NU21-08-00373)

Alzheimer´s disease (AD) is a progressive neurodegenerative disorder in the elderly population worldwide, underlaid by two pathological features in the AD brain: 1) extracellular beta-amyloid plaques (Aß) and 2) intraneuronal Tau-containing neurofibr...

Neurosciences (including psychophysiology)

  • 2021 - 2024
    • •
  • 15 237 tis. Kč
    • •
  • 15 237 tis. Kč
    • •
  • MZ
Project

Tracking SORLA function in patients with early onset Alzheimer’s disease (NU22J-08-00075)

Alzheimer´s disease (AD) is an incurable, progressive neurodegenerative disorder in the elderly population worldwide, manifested by progressive memory loss underlaid by two main pathological features in the AD brain: 1) extracellular beta-amyloid pla...

Neurosciences (including psychophysiology)

  • 2022 - 2025
    • •
  • 6 930 tis. Kč
    • •
  • 6 930 tis. Kč
    • •
  • MZ
  • 1 - 8 out of 8