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Výsledek výzkumu

INFRAFRONTIER??providing mutant mouse resources as research tools for the international scientific community

described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMAThe laboratory mouse is a ...

EB - Genetika a molekulární biologie

  • 2014
  • Jx
  • Odkaz
Výsledek výzkumu

A resource of targeted mutant mouse lines for 5,061 genes

The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles....

Genetics and heredity (medical genetics to be 3)

  • 2021
  • Jimp
  • Odkaz
Výsledek výzkumu

Neurodeficient Lurcher mutant mouse a useful model in experimental research of higher nervous functions

Lurcher mutant mice represent an animal model of olivocerebellar degeneration useful for studying the consequences of total functional elimination of the cerebellar cortex....

FH - Neurologie, neurochirurgie, neurovědy

  • 2004
  • Jx
Výsledek výzkumu

The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development

. The screen has produced mouse mutants of both known modifiers of epigenetic state mouse lines generated from the screen, MommeD6 and MommeD20, with point mutations in D14Abb1e. Theseare the first mouse mutant...

EB - Genetika a molekulární biologie

  • 2014
  • Jx
  • Odkaz
Výsledek výzkumu

Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene

Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene. Our results provide a model for functional studies of EPOR-triggered signaling pathways in erythropoiesis....

EB - Genetika a molekulární biologie

  • 2001
  • Jx
Výsledek výzkumu

Neuronal changes in healthy and defective mouse brain after high-frequency electromagnetic field exposure

We study the effect of HF EMF on neuronal aktivity in healthy and Lurcher mutant mice.

FH - Neurologie, neurochirurgie, neurovědy

  • 2005
  • D
Výsledek výzkumu

Disruption of the palatal rugae pattern in Tabby (eda) mutant mice

We showed statistically that the phenotypic variability seen in wild-type animals is further increased in Tabby mutants.

EB - Genetika a molekulární biologie

  • 2007
  • Jx
Výsledek výzkumu

Distribution and structure of the initial dental enamel formed in incisors of young wild-type and Tabby mice

The enamel in normal mouse incisors comprises three layers. We studied how this enamel structure develops in the incisors of wild-type and Tabby mutant (EDA wild-type and mutant incisors. In comparison to wild-type mice, en...

FF - ORL, oftalmologie, stomatologie

  • 2009
  • Jx
Výsledek výzkumu

From mice to men: lessons from mutant ataxic mice

Ataxic mutant mice can be used to represent models of cerebellar degenerative cell degeneration, Nervous, Staggerer, Weaver, Reeler, and Scrambler mouse models and mouse models of SCA1, SCA2, SCA3, SCA6, SCA7, SCA23, DRPLA,...

FH - Neurologie, neurochirurgie, neurovědy

  • 2014
  • Jx
  • Odkaz
Výsledek výzkumu

A limited role for SsrA/B in persistent Salmonella Typhimurium infections in pigs

and an ssrA/B mutant were compared in vitro and in vivo. The ssrA/B mutant strain a replication defect in mouse macrophages and was attenuated in a mouse model after oral that the ssrA/B mutant strain was...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2008
  • Jx
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