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9 983 (0,194s) •

Project

Protein truncation test for rapid detection of translation-terminating mutations. (IZ3700)

FG - Pediatrie

  • 1996 - 1998
    • •
  • 2 015 tis. Kč
    • •
  • 2 015 tis. Kč
    • •
  • MZ
Project

Titin-truncating variants as a cause of cardiomyopathy in humans genotype-phenotype correlations and predictors of disease severity (NW25J-02-00024)

truncation variants of a giant sarcomeric protein titin (TTNtv) that are present in 1.5 or controls) using RNA sequencing, Long Range PCR, and separation protein methods. We assume that the quantitative relation between wi...

Cardiac and Cardiovascular systems

  • 2025 - 2028
    • •
  • 6 996 tis. Kč
    • •
  • 6 996 tis. Kč
    • •
  • MZ
Project

Mutation analysis of the BRCA1 and BRCA2 genes early diagnostics of hereditary breast and ovarian cancer. (NC5882)

Analysis of germ-line mutations of BRCA1 and BRCA2 genes will be performed in breast and ovarian cancer families.The role of these genes in hereditary cancers should be explained in Czech population.......

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 1 418 tis. Kč
    • •
  • 1 418 tis. Kč
    • •
  • MZ
Project

Thermostability of proteins - mutagenesis of elongation factor Tu from Bacillus stearothermophilus (GA204/98/0863)

General rules governing thermostability of proteins are not well known on elongation factors Tu (EF-Tu). These GTP-binding proteins are essential components of protein synthesis. Within a wide range of organisms spanning fr...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 1 689 tis. Kč
    • •
  • 1 374 tis. Kč
    • •
  • GA ČR
Project

Role of truncated PPM1D in genome instability and cancer development (GA20-11931S)

of DNA damage. Protein phosphatase PPM1D is a negative regulator of the p53 pathway of the PPM1D are present in solid tumors and in leukemia patients. These truncating PPM1D consequences of PPM1D truncation on genome stabi...

Oncology

  • 2020 - 2022
    • •
  • 8 339 tis. Kč
    • •
  • 8 150 tis. Kč
    • •
  • GA ČR
Project

Role of deficient checkpoint barrier in cancerogenesis (GA16-19437S)

in cancer patients resulting in expression of truncated Wip1 phosphatase. Importantly, truncated Wip1 efficiently counteracts p53 function in the checkpoint. Here we propose to exploit our novel transgenic mouse model to test

FD - Onkologie a hematologie

  • 2016 - 2020
    • •
  • 7 368 tis. Kč
    • •
  • 6 822 tis. Kč
    • •
  • GA ČR
Project

Interactions of supercoiled DNA with tumor-supressor protein p53 (IAA5004803)

forms of p53 protein and its truncated form and of the effect of specific mutations this key protein exerts its multiple functions in the cell. The contemplated studies on the p53 protein binding to DNA including ...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 2 899 tis. Kč
    • •
  • 990 tis. Kč
    • •
  • AV ČR
Project

Phosphorylation-mediated signalling in DNA damage response and cancer (7F14061)

In this application we will investigate the following five aims: Aim I) Molecular mechanism of PPM1D/Wip1 phosphatase function in DDR Aim II) Role of truncating PPM1D mutations in colorectal cancer Aim III) Functional role of PP1 phosphatase...

FD - Onkologie a hematologie

  • 2014 - 2017
    • •
  • 25 520 tis. Kč
    • •
  • 25 520 tis. Kč
    • •
  • MŠMT
Project

Shell model of complex nuclei - procedures of truncation and applications to weak processes (IAA1048504)

BG - Jaderná, atomová a molekulová fyzika, urychlovače

  • 1995 - 1997
    • •
  • 320 tis. Kč
    • •
  • 320 tis. Kč
    • •
  • AV ČR
Project

Modulating ABA signaling pathways by alternative splicing of ABI2 (GA23-08067S)

to the production of truncated, dominant-negative protein isoforms interfering-negative ABI2 splice variants with other proteins connected with the ABA signaling with respect to the changes in the protein-prot...

Environmental biotechnology

  • 2023 - 2025
    • •
  • 8 312 tis. Kč
    • •
  • 8 312 tis. Kč
    • •
  • GA ČR
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