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15 (0,095s) •

Project

The correlation between expression of matrix metalloproteinases and their tissue inhibitors the influence of olomoucin (IZ3640)

FP - Ostatní lékařské obory

  • 1996 - 1998
    • •
  • 815 tis. Kč
    • •
  • 815 tis. Kč
    • •
  • MZ
Project

Inhibitors of cyclin-dependent kinases (cdc 2, cdk 2) derived from olomoucine (GA301/96/0437)

CE - Biochemie

  • 1996 - 1996
    • •
  • 0 tis. Kč
    • •
  • 1 956 tis. Kč
    • •
  • GA ČR
Project

Modulation of kinases for targeted treatment of haematological and other malignancies (GA23-05474S)

Activities of kinase inhibitors (bioisosteres of olomoucine, bohemine, roscovitine, olomoucine II, etc.) are being studied in our laboratories for a long time and the thousands of analogues already available should substantially he...

Hematology

  • 2023 - 2025
    • •
  • 9 990 tis. Kč
    • •
  • 9 990 tis. Kč
    • •
  • GA ČR
Project

Biological activity of new inhibitors of cyclin-dependent kinases (GP204/03/D231)

The discovery of olomoucine as one from the first specific inhibitors of cyclin-dependent kinases (cdk1, cdk2, cdk5) markedly stimulated the development of new generation of antimitotic drugs. Olomoucine and its novel derivatives wi...

CE - Biochemie

  • 2003 - 2006
    • •
  • 1 483 tis. Kč
    • •
  • 583 tis. Kč
    • •
  • GA ČR
Project

Modulation of CDK and related molecular targets in aggressive non-Hodgkin lymphomas (GA17-14007S)

We have established a massive, unique library of compounds (olomoucine, bohemine, roscovitine, olomoucine II, CAN508, and many others toward cell cycle kinases cdk1, cdk2, cdk5, ERK1) originally created to discover new cytokinins an...

FD - Onkologie a hematologie

  • 2017 - 2019
    • •
  • 8 907 tis. Kč
    • •
  • 8 502 tis. Kč
    • •
  • GA ČR
Project

Molecular Mechanism of Antiproliferative Effects of Growth Regulators Cytokinins and Related Compounds (GV204/96/K235)

Recently discovered unusual specifity of cytokinin derivative olomoucine OC; 2-(2-hydroxy-ethylamino)-6-benzylamino--9-methylpurin) toward cell cycle kinases by olomoucine. Preliminary data drom plant protoplasts, sea urchin embryos...

EA - Morfologické obory a cytologie

  • 1996 - 2000
    • •
  • 28 682 tis. Kč
    • •
  • 28 682 tis. Kč
    • •
  • GA ČR
Project

Cell cycle control in the pathogenic yeast Cryptococcus neoforman (ME 590)

, screening of derivatives of the CDK-inhibitors related to olomoucine is planned...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 1 111 tis. Kč
    • •
  • 668 tis. Kč
    • •
  • MŠMT
Project

Modulation od cyclin-dependent kinases in haematological malignancies (GA14-19590S)

We discovered unusual specificity of cytokinin derivative olomoucine (OC) toward cell cycle kinases (cdk1, cdk2, cdk5, ERK1). This discovery has led to subsequent development of bohemine, roscovitine, olomoucine II, CAN508 and many ...

FD - Onkologie a hematologie

  • 2014 - 2016
    • •
  • 8 568 tis. Kč
    • •
  • 8 568 tis. Kč
    • •
  • GA ČR
Project

Tentative isolation and identification of plant hormones cytokinins in (non) tumorous animal and human tissues (GA204/96/0391)

Detection of N6-substituted adenine derivatives (cytokonins) by specific ELISA in human blood, the dependence of level of endogenous cytokinin-like substances on development of human embryo, a high affinity of cytokinin derivatives (olomoucine

EF - Botanika

  • 1996 - 1998
    • •
  • 4 026 tis. Kč
    • •
  • 1 832 tis. Kč
    • •
  • GA ČR
Project

Biological activity of synthetic inhibitors of cyclin-dependent kinases (GA204/08/0511)

During our previous projects we have developed several new inhibitors of cyclin-dependent kinases. Most of the described inhibitors showed a preference for CDK1 and CDK2, important regulators of the cell cycle. However, olomoucine II, which ...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 3 200 tis. Kč
    • •
  • 3 200 tis. Kč
    • •
  • GA ČR
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