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177 (0,094s) •

Project

Mechanism of somatic hypermutation targeting in the B cell genome (GA22-30384S)

Somatic hypermutation (SHM) is a key process in diversification of antibodies, and modulation of their affinity in particular. This process is initiated by cytosine deamination by the activationinduced deaminase (AID) and completed ...

Cell biology

  • 2022 - 2024
    • •
  • 7 254 tis. Kč
    • •
  • 7 254 tis. Kč
    • •
  • GA ČR
Project

Mistargeting of somatic hypermutation and its role in B cell genome instability (GA15-24776S)

Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes in germinal center B cells during an immune response. The reaction is initiated by cytosine deamination by activation-induced deaminase (AID) and ...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 4 771 tis. Kč
    • •
  • 4 771 tis. Kč
    • •
  • GA ČR
Project

Characterization of B lymphocyte subpopulations in patients with common variable immunodeficiency. (NR9198)

1. Examination, quantification and more precise immunophenotypization of transitional and immature (CD21-) B cells in patients with CVID and comparison of the found proportions with the control group. 2. Evaluation of SHM frequency in rearranged Ig g...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2007 - 2009
    • •
  • 6 789 tis. Kč
    • •
  • 6 768 tis. Kč
    • •
  • MZ
Project

Disturbances of differentiation of B-lymphocytes in patients with defects of humoral immunity (NT11414)

The Ig-specific single-cell RT-PCR in B cells of patients with CVID, IgAD/IgMD will be used to analyze somatic hypermutation, affinity maturation/isotype switch, proliferation and activation, BCR signalling and differentiation stadi...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2010 - 2014
    • •
  • 9 894 tis. Kč
    • •
  • 9 894 tis. Kč
    • •
  • MZ
Project

Clonal expansions in chronic lymphocytic leukemia – (epi)genomic characterization towards better disease understanding (NW24-03-00052)

concordant somatic hypermutation status of immunoglobulin variable gene IGHV that could somatic variants for constructing clonal architecture and phylogenetic trees......

Oncology

  • 2024 - 2027
    • •
  • 15 347 tis. Kč
    • •
  • 15 347 tis. Kč
    • •
  • MZ
Project

Exploring the impact of somatic expansion rates on quantitative progression marker candidates (Voice) in early stages of Repeat Expansion Disorders (9F25002)

, and somatic expansion index and somatic expansion rate Aim 2: Study longitudinally and somatic expansion rate Aim 3: Analyze the correlation of change rates (somatic......

Clinical neurology

  • 2025 - 2028
    • •
  • 6 206 tis. Kč
    • •
  • 6 206 tis. Kč
    • •
  • MŠMT
Project

Interaction of exogenous and endogenous growth substances in somatic embryogenesis of Picea abies (OC 822.40)

Somatic embryogenesis of Norway spruce is studied both on solidified media and suspension cultures. Possibilities of use of liquid cultivation system are evaluated somatic embryo development, maturation, desiccation and germination ...

CE - Biochemie

  • 1997 - 1999
    • •
  • 1 405 tis. Kč
    • •
  • 755 tis. Kč
    • •
  • MŠMT
Project

SOMATIC AND NEUROPSYCHOLOGICAL DEVELOPMENT, MALFORMATION RATE AND MORBIDITY IN CHILDREN BORN AFTER INTRACYTOPLASMIC SPERM INJECTION (NR8118)

Study on somatic and neuropsychological development,malformation rate and morbidity in children born after intracytoplasmic sperm injection......

FK - Gynekologie a porodnictví

  • 2004 - 2007
    • •
  • 1 718 tis. Kč
    • •
  • 1 623 tis. Kč
    • •
  • MZ
Project

Cultivation and genetic factors affecting efficiency of conifer somatic embryogenesis (OC 843.50)

The project is focused on improvement of cultivation protocols for somatic embryogenesis of Norway spruce and silver fir. The possibility of production of seedlings derived by induction of embryogenic cultures of selected elite genotypes wil...

EI - Biotechnologie a bionika

  • 2000 - 2004
    • •
  • 5 090 tis. Kč
    • •
  • 1 725 tis. Kč
    • •
  • MŠMT
Project

Molecular characterization of adaptive antibiotic resistance and tolerance mechanisms of Staphylococcus aureus strains causing chronic infections (NV17-30460A)

resistance to antibiotics (persistence, target site mutation, hypermutability...

EE - Mikrobiologie, virologie

  • 2017 - 2020
    • •
  • 8 659 tis. Kč
    • •
  • 8 659 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 177