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137 (0,084s) •

Project

Phoshate-based drug delivery spacers to target fungal infections (GJ20-25137Y)

Drug delivery is one of the biggest challenges in medicinal chemistry. Modern pro-drugs use self-immolative (SI) spacers to control their cascade disassembling and drug release. We want to develop a novel phosphate based spacer, with improve...

Organic chemistry

  • 2020 - 2022
    • •
  • 5 697 tis. Kč
    • •
  • 5 697 tis. Kč
    • •
  • GA ČR
Project

Ferritin as a tool for enzymes-directed prodrug activation (NU21J-08-00043)

of enzymes for a catalytic activation of nontoxic prodrugs. In the project, advanced bio will be developed. In the project, broad spectrum of prodrugs inactivated by enzyme-sensitive protective masking moieties will be investigated...

Nano-materials (production and properties)

  • 2021 - 2024
    • •
  • 6 120 tis. Kč
    • •
  • 6 120 tis. Kč
    • •
  • MZ
Project

Tumor targeted prodrugs of glutamine antagonists (LTAUSA18166)

Synthesis of prodrugs of glutamine antagonist 6-diazo-5-oxo-L-norleucine with specific ability to release the parent drug in target cancer cells by the action of enzymes overexpressed in cancer tissues. Pharmacokinetic studies of synthesized...

Organic chemistry

  • 2019 - 2022
    • •
  • 8 040 tis. Kč
    • •
  • 6 368 tis. Kč
    • •
  • MŠMT
Project

Development of Novel Antituberculosis Agents and Prodrugs Effective against Multidrug Resistant Tuberculosis (MEB091034)

Our investigation is based on molecular modelling of new anti-tuberculosis drugs and prodrugs, their synthesis, antimycobacterial activity evaluation in vitro and searching for new mechanisms of activity. The aim of the research is the coope...

FR - Farmakologie a lékárnická chemie

  • 2010 - 2011
    • •
  • 112 tis. Kč
    • •
  • 112 tis. Kč
    • •
  • MŠMT
Project

Syntheses of new prodrug forms of biologically active nucleotide analogues (GA14-00522S)

and their transformation to novel non-toxic prodrugs mostly based on peptidomimetics or modified amino with their alternative prodrug forms (POM, alkoxyalkyl, trifluoroethyl esters, amidates) is also......

CC - Organická chemie

  • 2014 - 2016
    • •
  • 4 481 tis. Kč
    • •
  • 4 481 tis. Kč
    • •
  • GA ČR
Project

Preparation of Peptidomimetic Prodrugs of Acyclic Nucleoside Phosphonates as Antivirals with Improved Bioavailability (ME10040)

Transformation of acyclic nucleoside phosphonates (ANPs) to appropriate prodrugs helps to improve their low bioavailability connected with a limited transport through the cell membrane caused by a presence of negative charges in the molecule...

CC - Organická chemie

  • 2010 - 2012
    • •
  • 2 400 tis. Kč
    • •
  • 2 400 tis. Kč
    • •
  • MŠMT
Project

Hybrid biocompatible nanocatalysts for extracellular bioorthogonal activation of prodrugs (GM23-04740M)

liberation of cytotoxicity of non-toxic prodrugs. To achieve this, we plan four work and their encapsulation into ferritins, and synthesis of prodrugs, iii) investigation of reactivity......

Biochemistry and molecular biology

  • 2023 - 2027
    • •
  • 23 843 tis. Kč
    • •
  • 23 843 tis. Kč
    • •
  • GA ČR
Project

Advanced Carriers for Platinum Drugs (GA16-05961S)

Novel advanced carriers for platinum drugs and prodrugs will be developed in this project. The carriers will be based on macrocyclic cavitands, molecular capsules, and biocompatible polymers. The drug-carrier systems will be chemically and s...

CA - Anorganická chemie

  • 2016 - 2020
    • •
  • 9 763 tis. Kč
    • •
  • 9 763 tis. Kč
    • •
  • GA ČR
Project

Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains (NS10367)

antimicrobial active drugs and prodrugs which act predominantly against isolated human...

FR - Farmakologie a lékárnická chemie

  • 2009 - 2011
    • •
  • 4 303 tis. Kč
    • •
  • 4 303 tis. Kč
    • •
  • MZ
Project

Polymer prodrugs acting as endogenous vaccines for synergic tumor therapy using immunomodulation and immune checkpoint blockade (GA17-08084S)

The principal objective of the project is to study combined tumor treatment, benefiting from chemotherapy based on novel polymer prodrugs acting as endogenous vaccines, inhibition of suppressive activity of myeloid-derived suppressor cells (...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 8 334 tis. Kč
    • •
  • 8 010 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 137