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Study of apoptosis inhibitors as diagnostic and predictive tumor biomarkers in lung cancer (NR7860)
Analysis of expression of apoptosis inhibitors by molecular and biochemical methods in tumor tissue, lung parenchyma, biopsy and cytological samples and sputum from lung cancer patients and study of their significance as tumor biomarkers in lung canc...
FD - Onkologie a hematologie
- 2004 - 2008 •
- 9 173 tis. Kč •
- 8 553 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2004 - 31. 12. 2008
Uznané náklady
Podpora ze státního rozpočtu (93%)
Poskytovatel: Ministerstvo zdravotnictví
Role of caspase-2 in apoptosis induction by taxanes in breast cancer cells (GA301/09/0362)
It seems that caspase-2 can play a major role in apoptosis induction in cancer on differing expression of caspase-2L and caspase-2S that are two isoforms of caspase-2 to elucidation of the role of caspase-...
EB - Genetika a molekulární biologie
- 2009 - 2013 •
- 7 109 tis. Kč •
- 7 077 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2009 - 31. 12. 2013
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Study of expression and activation of apoptogenic caspases and of levels of their inhibitors in non-small cell lung carcinoma (NC6610)
Study of expression and activation of apoptogennic caspases and of levels of their inhibitors XIAP and survivin in human non-small cell lung carcinoma with the aim to evaluate their correlation with progression of this cancer disease.......
FD - Onkologie a hematologie
- 2001 - 2003 •
- 3 500 tis. Kč •
- 3 470 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2001 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
Apoptotic and non-apoptotic functions of caspases in hard tissue formation (GAP502/12/1285)
is apparently caspase dependent, but the complete functional network has not been clarified yet. Ourresults in caspase-9 and caspase-3 deficient mice show importance caspases, particularly in cell differentiation....
ED - Fyziologie
- 2012 - 2014 •
- 3 747 tis. Kč •
- 3 747 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2014
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Investigation of novel functions of caspases by their simultaneous quantification in individual cells (GA20-00726S)
functions of caspases in cell proliferation and differentiation at the single-cell level. While functions of caspases in apoptosis are well-known, the specific components of caspase cascades in the novel functions are not ...
Analytical chemistry
- 2020 - 2022 •
- 5 758 tis. Kč •
- 5 758 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2020 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Specification of osteogenic potential of caspases in context of craniofacial development (GA19-14727S)
osteoblasts differentiate from mesenchymal precursors. Caspases are known to contribute of their functions. The latest data indicate the presence of active caspases in non-apoptotic of caspase activity in osteoblastic cell...
Developmental biology
- 2019 - 2022 •
- 8 009 tis. Kč •
- 7 742 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 30. 6. 2022
Uznané náklady
Podpora ze státního rozpočtu (97%)
Poskytovatel: Grantová agentura České republiky
Mechanisms of programmed cell death completion in human tumor cells induction by iron deprivation (KJB5052401)
(Raji) B lymphomas. Cell death involved in Raji is not related to caspase-9, caspase-3 activation. The aim of this project is to describe the caspase-9, -3 will assess (1) the activation of executioner caspases-6,...
EB - Genetika a molekulární biologie
- 2004 - 2005 •
- 775 tis. Kč •
- 387 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2004 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (50%)
Poskytovatel: Akademie věd České republiky
Caspase-1 and chondrocytes integration of osteoarthritis oriented research (LUABA22019)
. Caspases are cysteine proteases well-known from apoptotic and inflammatory processes the effect of general caspase inhibition on expression of OA-related genes in healthy chondrocytes. However, the impact of individual cas...
Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])
- 2022 - 2024 •
- 1 190 tis. Kč •
- 1 190 tis. Kč •
- MŠMT
Řešení projektu: 1. 7. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Sensitization of leukemic cells to radiation-induced apoptosis by the death ligand TRAIL (GP202/02/D023)
arereleased from mitochondria to cytosol and caspase 9 is activated. Caspase 9 then activates effector caspase 3. Second apoptotic pathway begins by activation of so called direct activation of caspase 8, which ac...
BF - Elementární částice a fyzika vysokých energií
- 2002 - 2005 •
- 435 tis. Kč •
- 435 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2002 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Senescence and proteases – relevance to osteoarthritis and osteoporosis (LUC25127)
Specific aims of the Inter-COST project include: 1) Activation of caspases in senescent cells 2) Osteogenic markers after caspase inhibition in senescent cells with focus on clinically important markers associated with OA and OP 3) ...
Other biological topics
- 2025 - 2028 •
- 3 741 tis. Kč •
- 3 741 tis. Kč •
- MŠMT
Řešení projektu: 1. 9. 2025 - 31. 8. 2028
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
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