Filtry
Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker - Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase
Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylp...
FR - Farmakologie a lékárnická chemie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun - and paraoxon-inhibited acetylcholinesterase
Six AChE monooxime-monocarbamoyl reactivators with an (E)-but-2-ene linker were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by the nerve agent ta...
FP - Ostatní lékařské obory
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase
against all used OPs. In addition, the data indicate that a (E)-but-2-ene linker the reactivation kinetics of a homologous series of bispyridinium bis-oximes bearing a (E)-but-2-ene ...
FR - Farmakologie a lékárnická chemie
- 2012 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
Six potential bispyridinium reactivators were prepared and tested on inhibited acetylcholinesterase for their reactivation potency...
FR - Farmakologie a lékárnická chemie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
Six potential AChE reactivators were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by insecticide chlorpyrifos was tested in vitro. According to the results, (E)-1-(2
FP - Ostatní lékařské obory
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
RP-HPLC lipophilicity determination of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker
New acetylcholinesterase reactivators with either a (E) or (Z)-but-2-ene connecting linker were recently prepared. The purity of the compounds was checked by HPLC and was found to be sufficient for in-vitro screeni...
FP - Ostatní lékařské obory
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
TLC Analysis of Twelve Different Salts of Oxime HI-6-Reactivator of Nerve Agent Inhibited AChE
Four thin-layer chromatographic (TLC) methods for identification of twelve bisquaternary acetylcholinesterase reactivator HI-6 salts (sulfate, chloride, acetate, bromide, phosphate, mesylate, tartrate, iodide, malonate, salicylate, maleinate, and tos...
KA - Vojenství
- 2011 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation
DDVP-inhibited rat diaphragm AChE reactivation by oxime K027/K203 was dose-dependent. Dose-response relationships were described by 4-parameter exponential and Hill models. Maximum size of DDVP-inhibited AChE reactivation by K-oximes was 2.1-fold. Ox...
Toxicology
- 2019 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Synthesis and biological evaluation of some ring -substituted (E)-3-aryl-1-pyrazin-2-ylprop-2-en-1-ones
The title compounds were prepared by the Claisen-Schmidt condensation; their antifungal, antimycobacterial and photosynthesis-inhibiting activity were evaluated in vitro......
FR - Farmakologie a lékárnická chemie
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Copper complexes with derivatives of (E)-1-(2'-hydroxyphenyl)-3-phenylprop-2-en-1-one and their use as medicaments in antitumor therapy
The submitted technical solution from the area of antitumour drugs based on copper coordination compounds, relates to copper complexes involving (E)-1-(2'-hydroxyphenyl)-3-phenylprop-2-en-1-one derivatives and bide...
CA - Anorganická chemie
- 2016 •
- Fuzit •
- Odkaz
Rok uplatnění
Fuzit - Užitný vzor
Výsledek na webu
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