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72 (0,098s) •

Project

Molecularly guided radiotherapy or radiochemotherapy based on mikroRNA profile in head and neck cancer patients- a feasibility study. (NV15-31627A)

Radiotherapy is one of the cornerstones of head and neck cancer treatment. Intensification of treatment is improving therapeutic outcomes, but these are still not satisfactory. In our work we address the usage of microRNAs in connection with curative...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 11 546 tis. Kč
    • •
  • 9 929 tis. Kč
    • •
  • MZ
Project

Molecular-genetic markers for prediction of radiotherapy response in head and neck cancer (NV16-29835A)

Currently, there is no clinical marker which allows a pre-therapeutic selection of patients with head and neck tumors that would profit more from the conservative therapy or primary surgery, respectively. We meaningfully contribute to solution of thi...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 17 558 tis. Kč
    • •
  • 16 921 tis. Kč
    • •
  • MZ
Project

Process of aging in head and neck cancer patients (NU23J-07-00018)

Head and neck tumors are neoplasms arising from epithelial cells of the anatomical region and include tumors of the lips, oral cavity, nasal cavity, paranasal sinuses, salivary glands, larynx, and pharynx with head and neck squamous cell carcinoma be...

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 5 615 tis. Kč
    • •
  • 5 615 tis. Kč
    • •
  • MZ
Project

Nanotherapeutics delivering protease inhibitor and cytostatics for advanced treatment strategy of chemorefractory Head and Neck carcinomas (NU21-03-00273)

Head and neck squamous cell carcinoma (HNt) is the sixth most common cancer worldwide. Unfortunately, the prognosis of patients with non-resectable and advanced disease is highly unfavorable. Chemotherapy as a systemic mode of treatment necessary for...

Polymer science

  • 2021 - 2024
    • •
  • 17 535 tis. Kč
    • •
  • 17 535 tis. Kč
    • •
  • MZ
Project

Comparative transcriptomic analysis of regeneration in head and neck cancer as a new strategy to search cancer prognostic markers (NW24-03-00459)

Recently introduced high-throughput expression profiling at the individual cell level revolutionize our understanding about biological processes in normal and pathological situations. Novel cell types and regulatory networks have been revealed and ar...

Oncology

  • 2024 - 2027
    • •
  • 15 032 tis. Kč
    • •
  • 15 032 tis. Kč
    • •
  • MZ
Project

Effect of metabolic reprogramming of cancer associated fibroblasts on the prognosis of head and neck cancer patients (NU21-03-00223)

Tumor microenvironment consists of various cell populations, for example cancer associated fibroblasts. In many solid tumors, so-called metabolic symbiosis occurs, during which fibroblast-produced lactate serves as a source of carbon for cancer cells...

Cell biology

  • 2021 - 2024
    • •
  • 10 043 tis. Kč
    • •
  • 10 043 tis. Kč
    • •
  • MZ
Project

Cell interactions in tumour microenvironment as a new tool for therapy response prediction in head and neck cancer (NV18-08-00229)

Tumour microenvironment (TME) can activate protecting signalling pathways in tumour cells, especially when TME cells are damaged by chemotherapy. In this project, we will focus on cisplatin resistance conferred to cancer cells by TME. FaDu cells wil...

Otorhinolaryngology

  • 2018 - 2021
    • •
  • 15 398 tis. Kč
    • •
  • 15 398 tis. Kč
    • •
  • MZ
Project

Exosomal RNA produced by cancer-associated fibroblasts as a relevant marker in head and neck cancer prognosis (NU20J-08-00018)

Head and neck squamous cell carcinomas (HNSCC) are the fifth most common solid cancer. Unfortunately, no significant improvement has been achieved in HNSCC patient survival due to unpredictable therapy response and therapy resistance which may be sig...

Oncology

  • 2020 - 2023
    • •
  • 12 657 tis. Kč
    • •
  • 12 657 tis. Kč
    • •
  • MZ
Project

The proteome of extracellular vesicles – the unexplored area of intercellular communication in the tumor microenvironment of head and neck cancer (NU22-03-00202)

Head and neck squamous cell carcinoma (HNSCC) is common and severe solid cancer. Cancer-associated fibroblasts (CAFs) can promote HNSCC progression and therapy resistance by secreting factors contained in exosomes. Exosomes are released from CAFs and...

Otorhinolaryngology

  • 2022 - 2025
    • •
  • 10 468 tis. Kč
    • •
  • 10 468 tis. Kč
    • •
  • MZ
Project

The composition of the oral and intestinal microbiome as a predictor for response to therapy in patients with head and neck carcinoma (NU23-03-00274)

Head and neck squamous cell carcinomas (HNSCC) are the sixth most common cancer worldwide. About 70% of patients have an advanced stage of the disease and about 20% have a poor response to radiotherapy or chemoradiotherapy (RT/CRT). RT/CRT in such re...

Otorhinolaryngology

  • 2023 - 2026
    • •
  • 12 359 tis. Kč
    • •
  • 12 359 tis. Kč
    • •
  • MZ
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