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Interaktion of calreticulin with invertebrate antimicrobial lectins (IAA5020208)
Calreticulin has been reported as multifunctional calcium-binding protein acting as molecular chaperone for class I MHC antigen. More recently, it has been shown that calreticulin interacts with synthetic antimicrobial peptides deri...
EC - Imunologie
- 2002 - 2006 •
- 3 694 tis. Kč •
- 2 994 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2002 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (81%)
Poskytovatel: Akademie věd České republiky
The occurrence of autoantibodies to calreticulin and enterocytes in various autoimmune diseases and their diagnostic value (NI5051)
To improve diagnostic tools for celiac or other autoimmune diseases the occurrence, diagnostic sensitivity, specificity and predictive value of estimation of Abs to calreticulin and other enterocyte antigens will be tested. When the diagnost...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 1998 - 2000 •
- 2 041 tis. Kč •
- 1 824 tis. Kč •
- MZ
Řešení projektu: 1. 1. 1998 - 1. 1. 2000
Uznané náklady
Podpora ze státního rozpočtu (89%)
Poskytovatel: Ministerstvo zdravotnictví
Pathogenic role of autoantigens tissue transglutaminase and calreticulin in coeliac disease (ME 416)
The aim of our project is to study the role of autoantigens-tissue transglutaminase and calreticulin in coeliac disease, chronic disease of intestinal tissue. Autoantigens will be isolated and their localization and translocation in cells st...
EC - Imunologie
- 2001 - 2003 •
- 442 tis. Kč •
- 200 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 2001 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (45%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Occurrence, analysis of fine specificity and biological role of serum autoantibodies against calreticulin and tissue transglutaminase in patients with oncological diseases and selected risk groups (IAA500200709)
The mortality of patients with pancreatic tumors (PT) is frequently high due to late diagnosis. Appropriate serological marker for early stages of PT is still missing. Recently, serum autoantibodies (Ab) to calreticulin (CRT) have been found...
EC - Imunologie
- 2007 - 2011 •
- 2 857 tis. Kč •
- 2 857 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Akademie věd České republiky
Detailed analysis of specificity, heterogeneity and role of anti-calreticulin antibodies in oncological and autoimmune diseases. (GA13-14608S)
On the basis of previous studies, we shall perform analysis of the occurrence, levels and ratio of subtypes of serum anti-calreticulin (CRT) and try to elucidate their role in oncogenesis and estimate the clinical potential. We will test the...
FE - Ostatní obory vnitřního lékařství
- 2013 - 2019 •
- 3 526 tis. Kč •
- 3 526 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2013 - 29. 11. 2019
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of calreticulin in pathogenetic mechanism of coeliac disease and associated diseases (GA310/02/1470)
This project represents continuation of our studies focused on pathogenetic mechanisms of coeliac disease, gluten sensitive enteropathy. We have found that important autoantigen of epithelial origin is calreticulin (CRT). CRT, the Ca2+ bindi...
EC - Imunologie
- 2002 - 2004 •
- 3 076 tis. Kč •
- 2 340 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2002 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (76%)
Poskytovatel: Grantová agentura České republiky
Autoreactivity against calreticulin and tissue transglutaminase in coeliac disease and associated diseases (GP310/04/P242)
Coeliac disease (CLD) is a small intestinal disorder induced in genetically susceptible persons by ingestion of wheat gluten. Sera of patients with active CLD are characteristic by a high level of antibodies (Ab) to gliadin (part of gluten) and autoa...
EC - Imunologie
- 2004 - 2006 •
- 901 tis. Kč •
- 901 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of autoantigens tissue transglutaminase and calreticluin in the pathogeny of coeliac disease (ME 578)
The project is focused on the role of autoantigens in the development of severe, frequent, chronic disease of intestinal tissue of jejunum - coeliac disease. We have optimized the method of isolation of human recombinant autoantigen calreticulin<...
EC - Imunologie
- 2002 - 2003 •
- 522 tis. Kč •
- 362 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 2002 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (69%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
The localization of novel autoantigens and the role of autoantibodies in inflammatory bowel diseases (IAC5020103)
The aim of the project is the study of tissue and cell localization of newly identified autoantigens and its changes after stimulation by bacterial and/or food antigens. The localization will be studied in tissue section and also on cellular level. T...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2001 - 2001 •
- 288 tis. Kč •
- 262 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2001 - 1. 1. 2001
Uznané náklady
Podpora ze státního rozpočtu (91%)
Poskytovatel: Akademie věd České republiky
Multifunctional Polymer Systems with Cytostatic and Immunomobilizing Activities (IAAX00500803)
The aim of this interdisciplinary-oriented project is a study and understanding of patterns taking control of the relationship between the structure and physicochemical and biological properties of the tailor-made conjugates of synthetic macromolecul...
CD - Makromolekulární chemie
- 2008 - 2012 •
- 12 542 tis. Kč •
- 12 542 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2008 - 31. 12. 2012
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Akademie věd České republiky
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