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2 187 (0,051s) •

Project

Cancer immunotherapy rejuvenation of anti-cancer response by immune checkpoint blockade using novel multifunctional nanoparticle to block CTLA-4 and eliminate ICER (TH73020001)

targeting ICER in CTLA-4 positive T cells using mesoporous silica nanoparticles (MSNs specific paratopes trapping CTLA-4. Importantly, these peptides are meant not only to guide ICER RNAi delivery into CTLA

Polymer science

  • 2021 - 2023
    • •
  • 12 606 tis. Kč
    • •
  • 8 826 tis. Kč
    • •
  • TA ČR
Project

Studies of genetic associations of female reproductive disorders of autoimmune origin HLA class II and CTLA-4 genes (NH6451)

Study on associations of polymorphisms of HLA class II and CTLA-4 gene with female infertility positive for autoantibodies to zona pellucida and/or antiphospholipid autoantibodies.......

FK - Gynekologie a porodnictví

  • 2001 - 2003
    • •
  • 1 459 tis. Kč
    • •
  • 1 444 tis. Kč
    • •
  • MZ
Project

CTLA-4 Ig prophylactic monotherapy and combination with anti-CD4 and anti-TCR in rat aortic allograft model (IZ3060)

9F - 9

  • 1995 - 1996
    • •
  • 227 tis. Kč
    • •
  • 227 tis. Kč
    • •
  • MZ
Project

Non-HLA genetic risk of insulin dependent diabetes mellitus in Czech children a study of IDDM2 and IDDM1 2 genes (NE6503)

Study of non-HLA genetic risk of IDDM in the Czechpopulation. IDDM2 (insulin gene) and IDDM12 (CTLA-4 gene). Assessment of suitability for IDDM prediction. Comparison to other Caucasian populations. Correlation to IDDM incidence.......

FG - Pediatrie

  • 2001 - 2003
    • •
  • 1 267 tis. Kč
    • •
  • 1 264 tis. Kč
    • •
  • MZ
Project

Genetic factors influencing the development of celiac disease in Type 1 diabetic children. (NB7413)

Proposed study will investigate the contribution of susceptible genotypes (HLA-DQ, CTLA4 polymorphism, cytokine genes polymorphism) for the high frequency of celiac disease in children with Type 1 diabetes.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 1 815 tis. Kč
    • •
  • 1 808 tis. Kč
    • •
  • MZ
Project

Prognostic impact of biomarkers and variants in susceptibility genes in systemic lupus erythematosus (NW24J-10-00024)

the entire coding regions of the CTLA-4 and DNASE1 genes, as well as selected loci dysregulation. Next, we will focus on the soluble isoform of the CTLA-4 protein in the blood......

Rheumatology

  • 2024 - 2027
    • •
  • 6 831 tis. Kč
    • •
  • 6 831 tis. Kč
    • •
  • MZ
Project

Role of inhibitory immune checkpoints in Lyme disease (NU23-05-00302)

Immune checkpoints are receptors preventing excessive activation of the immune system and thus keeping the delicate balance between tolerance and immunopathology. Programmed cell death protein 1 (PD-1) and its ligand PD-L1, also CTLA-4

Microbiology

  • 2023 - 2026
    • •
  • 6 684 tis. Kč
    • •
  • 6 684 tis. Kč
    • •
  • MZ
Project

Polymer prodrugs acting as endogenous vaccines for synergic tumor therapy using immunomodulation and immune checkpoint blockade (GA17-08084S)

The principal objective of the project is to study combined tumor treatment, benefiting from chemotherapy based on novel polymer prodrugs acting as endogenous vaccines, inhibition of suppressive activity of myeloid-derived suppressor cells (MDSC) in ...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 8 334 tis. Kč
    • •
  • 8 010 tis. Kč
    • •
  • GA ČR
Project

Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy changing the paradigm (GA22-20548S)

. Most promising antitumor effect of IL-2/JES6 was observed when injected after CTLA-4 plus PD-1 blockage using even highly suboptimal dosage of respective blocking......

Oncology

  • 2022 - 2024
    • •
  • 8 330 tis. Kč
    • •
  • 8 330 tis. Kč
    • •
  • GA ČR
Project

Electrochemically active calix[4]arenes and their use for preparation of new receptors and (bio)sensors (GA13-21704S)

The project is focused on synthesis, fundamental electrochemical investigations and possible applications of electrochemically active calix[4]arenes as specific receptors and (bio)sensors in electroanalysis. The selected types of molecules i...

CG - Elektrochemie

  • 2013 - 2016
    • •
  • 8 517 tis. Kč
    • •
  • 8 517 tis. Kč
    • •
  • GA ČR
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