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2 187 (0,247s) •

Project

Cancer immunotherapy rejuvenation of anti-cancer response by immune checkpoint blockade using novel multifunctional nanoparticle to block CTLA-4 and eliminate ICER (TH73020001)

targeting ICER in CTLA-4 positive T cells using mesoporous silica nanoparticles (MSNs specific paratopes trapping CTLA-4. Importantly, these peptides are meant not only to guide ICER RNAi delivery into CTLA-4 positive T ce...

Polymer science

  • 2021 - 2023
    • •
  • 12 606 tis. Kč
    • •
  • 8 826 tis. Kč
    • •
  • TA ČR
Project

Electrochemically active calix[4]arenes and their use for preparation of new receptors and (bio)sensors (GA13-21704S)

The project is focused on synthesis, fundamental electrochemical investigations and possible applications of electrochemically active calix[4]arenes as specific receptors and (bio)sensors in electroanalysis. The selected types of molecules i...

CG - Elektrochemie

  • 2013 - 2016
    • •
  • 8 517 tis. Kč
    • •
  • 8 517 tis. Kč
    • •
  • GA ČR
Project

The impact of DPP-4 inhibitor therapy on immunity functions in patients with type 2 diabetes mellitus (NT12407)

Dipeptidyl peptidase 4 (DPP-4, identical to CD26) is multifunctional enzyme, participating on a number of immunoregulatory processes. In patients with the diabetes mellitus type 2 treated by DPP-4 inhibitors, changes DPP-

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2011 - 2015
    • •
  • 6 646 tis. Kč
    • •
  • 6 630 tis. Kč
    • •
  • MZ
Project

NMR relaxation study of thiacalix(4)arene derivatives (GP203/01/P066)

This project addresses physico-chemical properties of thiacalix[4]arene and series of its derivatives by means of advanced methods of nuclear magnetic resonance (NMR) spectroscopy that employ relaxation behaviour of nuclear spins Thiacalix[<...

CF - Fyzikální chemie a teoretická chemie

  • 2001 - 2003
    • •
  • 1 420 tis. Kč
    • •
  • 671 tis. Kč
    • •
  • GA ČR
Project

Studies of genetic associations of female reproductive disorders of autoimmune origin HLA class II and CTLA-4 genes (NH6451)

Study on associations of polymorphisms of HLA class II and CTLA-4 gene with female infertility positive for autoantibodies to zona pellucida and/or antiphospholipid autoantibodies.......

FK - Gynekologie a porodnictví

  • 2001 - 2003
    • •
  • 1 459 tis. Kč
    • •
  • 1 444 tis. Kč
    • •
  • MZ
Project

Membership and activities in ISO / IEC JTAG 4 (Joint Technology and Advisory Group 4) - Metrology (LA 109)

Group ISO / IEC JTAG 4 - Metrology, in co-operation with other groups, has the first priority object to establish a consistent metrological system, traceable to the international system of measurement standards......

JS - Řízení spolehlivosti a kvality, zkušebnictví

  • 2000 - 2003
    • •
  • 749 tis. Kč
    • •
  • 449 tis. Kč
    • •
  • MŠMT
Project

Development of the 4-door cabin for vehicles TATRA FORCE (EG15_018/0004320)

The aim of the project is to develop the cabin by making it unified with a basic two-door 4-seater design. Extending the cab and adding another pair of new low-profile doors will provide a transport capacity of up to 6 people.......

JO - Pozemní dopravní systémy a zařízení

  • 2015 - 2019
    • •
  • 4 159 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MPO
Project

Syntheses of the 4 - substituted nucleoside carba analogs with potentional antiviral effects (GA203/97/0375)

In continuation of the previous studies aimed at the syntheses of 4'-C-substituted deoxynucleosides with a potential antiviral activity, this research project concerns syntheses of novel 4'-substituted 2'-deoxynucleoside carba analo...

CC - Organická chemie

  • 1997 - 1999
    • •
  • 920 tis. Kč
    • •
  • 322 tis. Kč
    • •
  • GA ČR
Project

Difficult to control asthma bronchiale The significance of some cytokines in its pathogenesis and the possibility of therapeutic intervention. (IZ1960)

FR - Farmakologie a lékárnická chemie

  • 1994 - 1996
    • •
  • 296 tis. Kč
    • •
  • 442 tis. Kč
    • •
  • MZ
Project

CTLA-4 Ig prophylactic monotherapy and combination with anti-CD4 and anti-TCR in rat aortic allograft model (IZ3060)

9F - 9

  • 1995 - 1996
    • •
  • 227 tis. Kč
    • •
  • 227 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 2 187