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17 (0,056s) •

Project

Integrated genomics for advanced diagnostics of non-Hodgkin lymphomas and for decifering mechanisms of drug resistence (NU23-03-00172)

Non-Hodgkin lymphomas (NHLs) represent the most common type of hematologic in patients with newly diagnosed NHL are based on conventional immunohistochemistry, and copy number alterations. Mantle cell lymphoma (MCL) is a rare B-...

Hematology

  • 2023 - 2026
    • •
  • 18 224 tis. Kč
    • •
  • 18 224 tis. Kč
    • •
  • MZ
Project

Molecular Aspects of B-cell Receptor Signal Initiation as Targets for Specific Therapy of non-Hodgkin Lymphoma. (NV18-03-00117)

New and more specific therapies for non-Hodgkin lymphomas (NHL) are greatly needed, since standard treatment is based on a non-specific and highly toxic chemotherapy combination over 40 years old. The B-cell receptor (BCR) inhibition is such...

Oncology

  • 2018 - 2022
    • •
  • 11 156 tis. Kč
    • •
  • 11 156 tis. Kč
    • •
  • MZ
Project

Study of the role of genetic factors in non-Hodgkin´s lymphomas (NJ6747)

-control study of patients with nonHodgkin´s lymphomas (NHL) and compare DNA from blood will be assessed by PCR-RFLP in DNA from white blood cells. In DNA samples from NHL tumors efficiacy of therapeutic interventions for treatment ...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 4 954 tis. Kč
    • •
  • 2 072 tis. Kč
    • •
  • MZ
Project

Long-term Molecular Monitoring of Disease Course in Non Hodkin s Lymphoma (IZ4317)

Longitudinal monitoring and quantification of molecular in NHLs is proposed for the monitoring of disease course,treatment outcome and for an early prediction of relapses.......

FD - Onkologie a hematologie

  • 1997 - 1999
    • •
  • 2 043 tis. Kč
    • •
  • 1 681 tis. Kč
    • •
  • MZ
Project

Study of recombinant Interleukin 2/CETUS/ for patients after autologous bone marrow transplantation. (IZ2829)

9F - 9

  • 1995 - 1995
    • •
  • 0 tis. Kč
    • •
  • 1 900 tis. Kč
    • •
  • MZ
Project

The study of mech.of proto-oncog.activ.and tumor supressor genes inactiv.by fluresc.in situ hybridiz.(FISH)and compar. genomic hybridiz.(CGH)in pat.with non-Hodgkinś lymph.(NHL). (NC6209)

Characterization of types of genetic lession leading to activation of oncogenes and inactivation of tumor suppresor genes in three main types of NHL. Using fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH)...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 2 582 tis. Kč
    • •
  • 2 571 tis. Kč
    • •
  • MZ
Project

Molecular Genetic Monitoring of Patients with Non Hodgkins´ Lymphoma (GA312/98/0425)

Non-Hodkin Lymphomas (NHL) are relatively broad biologically not uniform group of malignant diseases, based on tumor proliferation of lymphoid cells clone. Incidence is growing in the last years and it is estimated on 10-15 cases in 100.000 ...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 2 519 tis. Kč
    • •
  • 2 519 tis. Kč
    • •
  • GA ČR
Project

The development of chimeric antigen receptors for the immunotherapy of lymphoma. (NT14030)

T cells will be obtained from the blood of patients with B-NHL and will be stimulated with anti-CD3/CD28 antibodies and transduced with CD20 CAR lentivirus. We will work out procedures for large-scale T cell cultivation under GMP quality set...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 435 tis. Kč
    • •
  • 7 435 tis. Kč
    • •
  • MZ
Project

Lime-based injection grouts with biopolymeric and biotech admixtures to repair the surfaces of historic architecture (GA25-15748S)

The project is devoted to the investigations of the effect of biopolymers and biotech admixtures on the rheological and mechanical properties of lime-pozzolan and NHL injection grouts on the repair of damaged surfaces of historical architect...

Civil engineering

  • 2025 - 2027
    • •
  • 4 740 tis. Kč
    • •
  • 4 740 tis. Kč
    • •
  • GA ČR
Project

Next generation CAR-T cells for the therapy of hematological malignancies (NU23-03-00188)

The proposed project deals with new methods of cell therapy of hematological malignancies such as AML, B-ALL and B-NHL using CAR-T T lymphocytes. The aim of the project trial in patients with refractory/relapsing B-ALL/B-NHL. Trea...

Hematology

  • 2023 - 2026
    • •
  • 13 368 tis. Kč
    • •
  • 13 368 tis. Kč
    • •
  • MZ
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