Filtry
NMR characterization of intrinsically disordered microtubule associated protein 2c
Microtubule-associated protein 2c (MAP2c) is an intrinsically disordered 49kDa protein expressed in developing nerve cells. MAP2c interacts with microtubules, affecting their dynamics, and plays an important role in neuronal morphog...
Biochemistry and molecular biology
- 2017 •
- O •
- Odkaz
Rok uplatnění
O - Ostatní výsledky
Výsledek na webu
Quantitative mapping of microtubule-associated protein 2c (MAP2c) phosphorylation and regulatory protein 14-3-3 zeta-binding sites reveals key differences between MAP2c and its homolog Tau
Microtubule-associated protein 2c (MAP2c) is involved in neuronal development of MAP2c in microtubule dynamics. We found that MAP2c and Tau significantly differ of unphosphorylated and phosphorylated MAP2c responsi...
Biological sciences
- 2017 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics
Microtubule-associated protein 2c (MAP2c) is a 49-kDa intrinsically disordered protein regulating the dynamics of microtubules in developing neurons. MAP2c differs by cAMP-dependent protein kinase (PKA). Moreover, the mechanisms thr...
Biochemistry and molecular biology
- 2018 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Conformation and dynamics of intrinsically disordered microtubule associated protein 2c
Microtubule associated protein 2c (MAP2c) regulates structure and dynamics (polymerization and degradation) of microtubules in developing neurons and other cells. MAP2c one contains several phosphorylation sites. The second importan...
Biochemistry and molecular biology
- 2018 •
- O •
- Odkaz
Rok uplatnění
O - Ostatní výsledky
Výsledek na webu
Structural basis of binding the unique N-terminal domain of microtubule-associated protein 2c to proteins regulating kinases of signaling pathways
-terminal region of MAP2c (N-MAP2c) to the dimerization/docking domains of the complexes. We have solved solution structure of N-MAP2c in complex with RIIDD2, confirming formation of an amphiphilic a-helix of MAP2c...
Biochemistry and molecular biology
- 2024 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Specific phosphorylation of microtubule-associated protein 2c by extracellular signal–regulated kinase reduces interactions at its Pro-rich regions
in the embryonic MAP2 variant MAP2c. We carried out real-time monitoring of phosphorylation relying on specific antibodies. Our comparison with the phosphorylation of MAP2c by a model cyclin-dependent kinase CDK2 and with phosphory...
Biochemistry and molecular biology
- 2022 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Structure and Functions of Microtubule Associated Proteins Tau and MAP2c: Similarities and Differences
of tau (tau40), and a 467-residue isoform of MAP2, known as MAP2c. For both molecules and MAP2c. Their interactions are further regulated by post-translational modifications between biological activities of tau40 and MAP2c...
Biochemistry and molecular biology
- 2019 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Efficient protocol for backbone and side-chain assignments of large, intrinsically disordered proteins: transient secondary structure analysis of 49.2 kDa microtubule associated protein 2c
Microtubule-associated proteins (MAPs) are abundantly present in axons and dendrites, and have been shown to play crucial role during the neuronal morphogenesis. The period of main dendritic outgrowth and synaptogenesis coincides with high expression...
BO - Biofyzika
- 2013 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
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