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Výsledek výzkumu

Improvement of Glibenclamide Water Solubility by Nanoparticle Preparation

Glibenclamide, a drug used for the treatment of type 2 diabetes, belongs, but poorly water-soluble drug. Nanoparticles of glibenclamide were prepared by an emulsion solvent evaporation method using dichloromethane as a solvent of

Medicinal chemistry

  • 2019
  • Jimp
  • Odkaz
Výsledek výzkumu

Glibenclamide instead of insulin: A new chance for patients with MODY3 diabetes. Case report

A case report on siblings with MODY3 diabetes and a successfull transfer from insulin therapy to administration of OHA.

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006
  • Jx
Výsledek výzkumu

Glibenclamide instead of insulin: a new chance for patients with MODY 3 diabetes: Case report

Work describes a new treatment modality in patients with diagnosed MODY 3 diabetes - treatment with peroral antidiabetics. It is presented on the example of a pair of siblings with MODY 3 diabetes....

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006
  • Jx
Výsledek výzkumu

Half-life of sulfonylureas in HNF1A and HNF4A human MODY patients is not prolonged as suggested by the mouse Hnf1a-/- mo

glibenclamide/glyburide were administered sequentially to seven HNF1A/HNF4A MODY subjects in the MODY and control subjects, respectively. The half-life of glibenclamide and glibenclamide treatment were highly correlated. W...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015
  • Jx
Výsledek výzkumu

Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant

A method for the separation of six selected antihyperglycemic (antidiabetic) drugs (tolbutamide, gliclazide, glimepiride, glibenclamide, repaglinide, and glipizide) was developed with use of micellar electrokinetic chromatography. Two non fo...

CB - Analytická chemie, separace

  • 2009
  • Jx
Výsledek výzkumu

Biphasic insulin aspart 30 plus metformin: an effective combination in type 2 diabetes

Biphasic insulin aspart 30 plus metformin: an effective combination in type 2 diabetes...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006
  • Jx
Výsledek výzkumu

Determinants of reperfusion arrhythmias: action potential duration versus dispersion of repolarization

between the earliest and latest RTs). Pinacidil (0.3 mg/kg) and glibenclamide (2 mg/kg application of glibenclamide prolonged APD in the ischemic and perfused zones, decreased to the control and glibenclamide groups. In co...

Pathology

  • 2021
  • Jimp
  • Odkaz
Výsledek výzkumu

The aggressiveness of succinate dehydrogenase subunit B-deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide

-deficient cells to glibenclamide, a specific K-ATP inhibitor, or to ATP caused that glibenclamide not only reduced the outward potassium currents in SDHB-deficient cells......

Endocrinology and metabolism (including diabetes, hormones)

  • 2023
  • Jimp
  • Odkaz
Výsledek výzkumu

Antidiabetic effect of Cleome droserifolia aerial parts: Lipid peroxidation-induced oxidative stress in diabetic rats

The article investigates the antidiabetic as well as the effect on lipid peroxidation of three different doses (50, 100, and 200 mg/kg) of Cleome droserifolia aerial parts methanolic extract in comparison with glibenclamide in alloxan-induce...

FR - Farmakologie a lékárnická chemie

  • 2005
  • Jx
Výsledek výzkumu

Half-Life of Sulfonylureas in HNF1A and HNF4A Human MODY Patients is not Prolonged as Suggested by the Mouse Hnf1a(-/-) Model

. Design and Methods Single doses of 3 mg glipizide and 5 mg glibenclamide/glyburide...

FR - Farmakologie a lékárnická chemie

  • 2015
  • Jx
  • Odkaz
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