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80 (0,066s) •

Project

Ribosome biogenesis in apoptosis and aging (MEB061009)

The study of apoptosis and ribosome associated cellular aging will be used in this research proposal to investigate the effect of ribosome biogenesis on these processes the effect of gene dosage variation of selected regulators of ribosome <...

EB - Genetika a molekulární biologie

  • 2010 - 2011
    • •
  • 90 tis. Kč
    • •
  • 90 tis. Kč
    • •
  • MŠMT
Project

Mitochondrial biogenesis of iron-sulfur centers as a therapeutic target against infections and diseases (LUC24134)

Identification of specific and targeted chelators of mitochondrial iron and description of their effect on the biogenesis of iron-sulphur centres......

Microbiology

  • 2024 - 2026
    • •
  • 4 843 tis. Kč
    • •
  • 4 843 tis. Kč
    • •
  • MŠMT
Project

Molecular mechanism of spliceosomal snRNP formation (GA21-04132S)

Small nuclear ribonucleoprotein (snRNP) particles are key components of the spliceosome that catalyzes pre-mRNA splicing. The biogenesis of snRNP particles takes to allow loading of Sm proteins onto snRNA. This is the first step in snRNP

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 9 023 tis. Kč
    • •
  • 9 023 tis. Kč
    • •
  • GA ČR
Project

The role of FtsH proteases in biogenesis of thylakoid membranes and photosynthetic complexes in cyanobacteria (GJ19-08900Y)

of FtsHs in PSII and PSI de novo assembly and TM biogenesis. We will focus on FtsHs assembly under conditions inducing TM biogenesis. We will also isolate sections......

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 5 445 tis. Kč
    • •
  • 5 445 tis. Kč
    • •
  • GA ČR
Project

Mechanism of ATP synthase biogenesis and the role of TMEM70 protein (GAP303/11/0970)

ATP synthase is the key enzyme of mitochondrial energy provision, responsible for production of most cellular ATP. Enzyme biogenesis results from expression of both nuclear and mtDNA genes encoding 16 different types of enzyme subunits of ma...

CE - Biochemie

  • 2011 - 2015
    • •
  • 8 963 tis. Kč
    • •
  • 8 963 tis. Kč
    • •
  • GA ČR
Project

Intertwined biogenesis of photosystems I and II born together to work together (GX19-29225X)

auxiliary proteins. PSI biogenesis is expected to use distinct machinery and its early phase remains unclear. However, recent data indicate that biogenesis of both......

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 48 724 tis. Kč
    • •
  • 48 724 tis. Kč
    • •
  • GA ČR
Project

The role of SURF1 protein in cytochrome c oxidase biogenesis (GA22-21552S)

Cytochrome c oxidase (COX) is a key enzyme of mitochondrial energetics providing ATP in mammalian cells. COX biogenesis integrates sequential assembly of 14 subunits, encoded by nuclear and mitochondrial genes. It depends on numerous ancilla...

Biochemistry and molecular biology

  • 2022 - 2025
    • •
  • 6 313 tis. Kč
    • •
  • 6 313 tis. Kč
    • •
  • GA ČR
Project

Genetic bases of cytochrome c oxidase deficiency (NS10581)

-encoded subunits of COX and cellular levels of copper in the biogenesis of cytochrome c oxidase complex will be studied. Analyses of the COX biogenesis......

FG - Pediatrie

  • 2009 - 2011
    • •
  • 8 608 tis. Kč
    • •
  • 8 478 tis. Kč
    • •
  • MZ
Project

Role of the cytoplasmic domain of the NMDA receptor for its biogenesis, function, and pharmacology Focus on disease-associated mutations (GA20-17945S)

of the intracellular C-terminal domain (CTD) in the regulation of NMDA receptor biogenesis mutations for the biogenesis, function and pharmacology of triheteromeric NMDA receptors......

Neurosciences (including psychophysiology)

  • 2020 - 2022
    • •
  • 10 108 tis. Kč
    • •
  • 10 041 tis. Kč
    • •
  • GA ČR
Project

Biogenesis and regulation by degradation of model yeast transporters (GA204/96/1315)

Biogenesis and regulation by degradation of two model yeast transporters, Can1 and Ga12, mediating the uptake of basic amino acids (Can1) and galactose (Ga12) across the plasma membrane will be studied at the molecular level. We plan to prov...

CE - Biochemie

  • 1996 - 1998
    • •
  • 2 134 tis. Kč
    • •
  • 1 690 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 80