Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F07%3A00000798" target="_blank" >RIV/00023001:_____/07:00000798 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats
Original language description
Arterial allografts are used nowadays as a modality in the treatment of vascular prosthesis infections. Prolonged administration of immunosuppressive drugs seemed to be essential for long time patency rates of alloarterial vascular reconstructions. Nevertheless, the use of immunosuppressives if there exists an acute infection is controversial. The experimental work described herein studied effects of a delayed low-dose FK 506 administration on the development of acute rejection changes 30 days after aortal transplantation in rats. The response of the recipient's immune system to aortal wall antigens of the donor in the field of no immunosuppression resulted in an intimal proliferation and its infiltration by immunocompetent cells of the recipient, necrosis of medial smooth muscle cells, including deposition of immunoglobulines, and a massive adventitial infiltration of CD4 and CD8 positive cells. On the other hand, all the principal histological signs of rejection listed above were sup
Czech name
Opožděné podávání FK 506 je dostatečné k potlačení akutních rejekčních změn po transplantaci aorty u potkanů.
Czech description
aortální štěpy, FK 506, potkany, transplantace

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Project
<a href="/en/project/NR7965" target="_blank" >NR7965: Fresh arterial allograft in vascular surgery</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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