A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F09%3A00001970" target="_blank" >RIV/00023001:_____/09:00001970 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12110/09:00010228

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies

Original language description

Recently, the role of the FTO gene in obesity development was described in west-European, but not in oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO SNP is associated with BMI in the Slavic population and to analyzeif there could be sex-specific effects of the SNP on BMI, WHR and lipid parameters. We have analyzed three large population based samples consisting of the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females). FTO rs17817449 SNPwas related to BMI in males (p = 0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal (p = 0.035) but not in premenopausal females (FSH < 40 U/L was used like marker of the premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analysed groups. These results suggest that, the effect of FTO SNP rs17817449

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/1M0510" target="_blank" >1M0510: Centre for cardiovascular research</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical chemistry and laboratory medicine

ISSN

1434-6621

e-ISSN

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Volume of the periodical

47

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

4

Pages from-to

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UT code for WoS article

000266014200002

EID of the result in the Scopus database

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