Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00055866" target="_blank" >RIV/00023001:_____/12:00055866 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0009898112001696" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0009898112001696</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cca.2012.03.025" target="_blank" >10.1016/j.cca.2012.03.025</a>

Result language
angličtina
Original language name
Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study
Original language description
The FTO gene plays an important role in the determination of body weight and BMI and it has been suspected of being associated with all-cause mortality, cardiovascular disease, cancer and end stage renal disease, but the causal mechanism of these effectsis still unknown. One of the possibilities is the potential association with telomere length. Telomeres are repetitive DNA-sequences located at the ends of eukaryotic chromosomes' length of which is reduced in all somatic cells during ageing. Out of the908 females (3PMFs study), in 783 females both FTO 1st intron tagging polymorphism (G>T, rs17817449) and the relative telomere length were successfully analysed. The relative telomere length was calculated as the ratio of telomere repeats to single-copygene copies. The frequencies of the FTO genotypes were similar to other populations (GG = 18.3%, GT = 49.1% and TT = 32.6%). We have detected, that the relative telomere length was significantly shorter (P<0.02, P<0.01 after adjustment f
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/NS10511" target="_blank" >NS10511: The effect of reproduction age on the sensitiveness of vascular wall to external, metabolic and genetic cardiovascular risk factors, longitudinal population study</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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