Prague hereditary hypercholesterolemic (PHHC) rat - a model of polygenic hypercholesterolemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F09%3A00002124" target="_blank" >RIV/00023001:_____/09:00002124 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/09:00202194
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Prague hereditary hypercholesterolemic (PHHC) rat - a model of polygenic hypercholesterolemia
Original language description
Prague hereditary hypercholesterolemic (PHHC) rat ? rat strain crossbred from Wistar rats ? is a model of hypercholesterolemia induced by dietary cholesterol. Importantly, no bile salts and/or antithyroid drugs need to be added to the diet together withcholesterol to induce hypercholesterolemia. PHHC rats have only modestly increased cholesterolemia when fed a standard chow and develop hypercholesterolemia exceeding 5 mmol/l on 2 % cholesterol diet. Most of the cholesterol in hypercholesterolemic PHHCrats is found in VLDL that become enriched with cholesterol (VLDL-C/VLDL-TG ratio > 1.0). Concurrently, both IDL and LDL concentrations rise without any increase in HDL. PHHC rats do not markedly differ from Wistar rats in the activities of enzymes involved in intravascular remodelation of lipoproteins (lipoprotein and hepatic lipases and lecithin:cholesterol acyltransferase), LDL catabolism, cholesterol turnover rate and absorption of dietary cholesterol. The feeding rats with choles
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9401" target="_blank" >NR9401: The role of dietary cholesterol in regulation of gene expression in the model of dietary induced hypercholesterolemia</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
suppl. 2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
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UT code for WoS article
000273537200010
EID of the result in the Scopus database
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