Reverse transport of cholesterol is the reason for resistance to development of atherosclerosis in Prague Hereditary Hypercholesterolemic (PHHC) Ra

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059074" target="_blank" >RIV/00023001:_____/14:00059074 - isvavai.cz</a>

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/63/63_591.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/63/63_591.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Reverse transport of cholesterol is the reason for resistance to development of atherosclerosis in Prague Hereditary Hypercholesterolemic (PHHC) Ra

Original language description

The Prague Hereditary Hypercholesterolemic (PHHC) rat is a model of hypercholesterolemia. In previous experiments, it was found to be completely resistant to the development of atherosclerosis. It was assumed that the reverse transport of cholesterol (RCT) might be the reason for this resistance. In this study, RCT was measured in vivo by cholesterol efflux from macrophages to plasma, using previously established methods for RCT in mice (Rader 2003), optimized for measurements in rats. Primary cell culture of macrophages was labeled with (14)C-cholesterol and then injected intraperitoneally into rats. Plasma and feces were collected at 24 and 48 h. The plasma (14)C-cholesterol levels at both 24 and 48 h were significantly higher in male PHHC rats compared to control Wistar rats. The PHHC rats excreted less (14)C-cholesterol in feces in 24 and 48 h compared to Wistar rats. The largest pool of (14)C-cholesterol was found in the adipose tissue of PHHC rats and in contrast lower levels of

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

591-596

UT code for WoS article

000345590100009

EID of the result in the Scopus database

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