The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in general population

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056415" target="_blank" >RIV/00023001:_____/12:00056415 - isvavai.cz</a>
Alternative codes found
RIV/75010330:_____/12:00009878
Result on the web
<a href="http://ndt.oxfordjournals.org/content/27/3/1030.full" target="_blank" >http://ndt.oxfordjournals.org/content/27/3/1030.full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/ndt/gfr418" target="_blank" >10.1093/ndt/gfr418</a>

Result language
angličtina
Original language name
The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in general population
Original language description
Background. Genome-wide association studies identified the FTO (fat mass and obesity gene) gene as an important determinant of body weight. More recently, the FTO gene was reported to be associated with other outcomes, including major risk factors for chronic kidney disease (CKD). We investigated the role of this gene in the risk of end-stage renal disease (ESRD) caused by CM). Methods. We conducted two large population-based case control studies of ESRD. Study 1 compared 984 haemodialysed patients withESRD with 2501 participants in the Czech post-MONICA study; Study 2 compared 1188 patients included in a kidney transplantation programme for ESRD with 6681 participants in the Czech HAPIEE study. The frequencies of the FTO rs17817449 single nucleotidepolymorphism genotype were compared between cases and controls. Results. The FTO rs17817449 genotype was significantly associated with CKD in both studies (P-values 0.00004 and 0.006, respectively). In the pooled data, the odds ratios of
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/NR7958" target="_blank" >NR7958: Genetic basis of syndrome MIA (Malnutrition - Inflammation - Atherosclerosis) - complication of hemodialysis treatment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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