Tacrolimus inhibits intimal hyperplasia in arterialised veins in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056485" target="_blank" >RIV/00023001:_____/12:00056485 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2012_001" target="_blank" >10.4149/BLL_2012_001</a>

Result language

angličtina

Original language name

Tacrolimus inhibits intimal hyperplasia in arterialised veins in rats

Original language description

Objectves: We investigated whether tacrolimus (FK506) can inhibit neointimal formation in arterialised vein grafts in rats. Methods: Lewis iliolumbar veins were implanted into the abdominal aorta of isogeneic rats. Animals in the treatment groups had daily intramuscular injections of tacrolimus at 0.2 mg/kg (group B) and 0.1 mg/kg (Group C), respectively. The control group A had no treatment. Light microscope evaluations of arterialised vein grafts were performed 30 days after operation. We determined the presence of endothelial cells, the thickness of intima and media, and the degree of infiltration by MHC class II positive, CD4 positive, and CD8 positive cells into the adventitia. Results: The intimal thickness in group B (5.0 +/- 1.0 mu m) was statistically lower (P < 0.05) when compared to group C (7.0 +/- 3.0 mu m). The intimal thickness in untreated group A (12.7 +/- 7.0 mu m) was statistically higher (P < 0.01) when compared to both treated groups B and C, respectively. The medi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

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Volume of the periodical

113

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

5

Pages from-to

5-9

UT code for WoS article

000299665400001

EID of the result in the Scopus database

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