The minimal dose of FK506 is sufficient to facilitate the arterialisation of venous allografts in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058657" target="_blank" >RIV/00023001:_____/13:00058657 - isvavai.cz</a>

Result on the web

<a href="http://download.springer.com/static/pdf/4/art%253A10.1007%252Fs10353-012-0179-3.pdf?auth66=1387707005_8145352df6c7ee8a18b39cf19059a6d0&ext=.pdf" target="_blank" >http://download.springer.com/static/pdf/4/art%253A10.1007%252Fs10353-012-0179-3.pdf?auth66=1387707005_8145352df6c7ee8a18b39cf19059a6d0&ext=.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10353-012-0179-3" target="_blank" >10.1007/s10353-012-0179-3</a>

Result language

angličtina

Original language name

The minimal dose of FK506 is sufficient to facilitate the arterialisation of venous allografts in rats

Original language description

We investigated whether a minimal dose of FK506 is sufficient to inhibit the rejection of venous allografts and facilitate allograft adaptation to arterialisation in rats. Iliolumbar veins from Brown Norway (BN) rats were transplanted into the abdominalaorta of Lewis (LEW) rats. Recipient animals received daily intramuscular injections of 0.1 mg kg(-) (1) FK506. Light microscope evaluations of grafts were performed 30 days after transplantation. We investigated the presence of endothelial cells, the intensity of intimal proliferation, the deposition of immunoglobulin G molecules into the medial layer and the degree of adventitial infiltration by Lewis MHC class II-positive, CD4-positive and CD8-positive cells. All results were compared to previously reported data for syngeneic, allogeneic non-immunosuppressed and allogeneic FK506-low-dose immunosuppressed animals. All alloveins under minimal FK506 immunosuppression showed typical histological signs of arterialisation 30 days after tra

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European surgery

ISSN

1682-8631

e-ISSN

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Volume of the periodical

45

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

8-14

UT code for WoS article

000315446600003

EID of the result in the Scopus database

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