Effect of acute hyperinsulinemia on brain metabolism evaluated by 1H MR spectroscopy - a Pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00058993" target="_blank" >RIV/00023001:_____/14:00058993 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/14:#0000461

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/63/63_513.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/63/63_513.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of acute hyperinsulinemia on brain metabolism evaluated by 1H MR spectroscopy - a Pilot study

Original language description

To determine whether acutely-induced supraphysiological hyperinsulinemia influences brain metabolism in patients with type 1 diabetes (D) and healthy controls (C) as detected by MR Spectroscopy. Group D consisted of 4 patients with the average duration of diabetes for 7 years. They were matched according to age, sex and BMI to 4 healthy controls. 1H MR Spectroscopy was performed with a 1.5 Tesla. Spectra were obtained from parietooccipital white matter repeatedly during a 3-h hyperinsulinemic euglycemicclamp with 2 mU.kg(-1).min(-1). In group D, significantly lower basal concentrations of N-acetylaspartate (p=0.02), choline (p=0.03), creatine (p=0.002) and inositol (p=0.007) were detected compared to C. After the induction of hyperinsulinemia, concentrations of choline, creatine, GABA, inositol, lactate, NAA and composite signal glutamate + glutamine (Glx) stayed stable. The detection of glucose signal is less realiable at 1.5 Tesla but we registered the alteration in glucose concentr

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

513-519

UT code for WoS article

000342568400012

EID of the result in the Scopus database

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