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Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059055" target="_blank" >RIV/00023001:_____/14:00059055 - isvavai.cz</a>

  • Result on the web

    <a href="http://annalsoftransplantation.com/abstract/index/idArt/889870" target="_blank" >http://annalsoftransplantation.com/abstract/index/idArt/889870</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.12659/AOT.889870" target="_blank" >10.12659/AOT.889870</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats

  • Original language description

    Background: Arterial allografts are used as vascular conduits in the treatment of prosthetic graft infection. Immunosuppression decreases their rupture risk rate. However, immunosuppression can be unprofitable in florid infection. Previously, we confirmed inhibition of cell-mediated destruction of rat aortic grafts by delayed use of tacrolimus. In this work, we studied the influence of this protocol on the antibody-mediated rejection. Material/Methods: Flow cytometry was used for the retrospective analysis of day 0, 14, and 30 sera obtained from Lewis rat recipients of isogeneic fresh infrarenal aortic grafts (group A) or Brown-Norway rat aortic grafts (group B, C, D) for the presence of donor-specific anti-MHC class I and II antibodies. Tacrolimus indaily dose of 0.2 mg/kg was administered from day 1 to day 30 (group C) or from day 7 to day 30 (group D). Results: Inhibition of fluorescence-labeled anti-BN-MHC class I and MHC class II antibodies binding to BN-splenocytes was observed

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FJ - Surgery including transplantology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Annals of transplantation

  • ISSN

    1425-9524

  • e-ISSN

  • Volume of the periodical

    19

  • Issue of the periodical within the volume

    may

  • Country of publishing house

    PL - POLAND

  • Number of pages

    8

  • Pages from-to

    225-232

  • UT code for WoS article

    000342976000001

  • EID of the result in the Scopus database