Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059055" target="_blank" >RIV/00023001:_____/14:00059055 - isvavai.cz</a>
Result on the web
<a href="http://annalsoftransplantation.com/abstract/index/idArt/889870" target="_blank" >http://annalsoftransplantation.com/abstract/index/idArt/889870</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.12659/AOT.889870" target="_blank" >10.12659/AOT.889870</a>
Alternative languages
Result language
angličtina
Original language name
Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats
Original language description
Background: Arterial allografts are used as vascular conduits in the treatment of prosthetic graft infection. Immunosuppression decreases their rupture risk rate. However, immunosuppression can be unprofitable in florid infection. Previously, we confirmed inhibition of cell-mediated destruction of rat aortic grafts by delayed use of tacrolimus. In this work, we studied the influence of this protocol on the antibody-mediated rejection. Material/Methods: Flow cytometry was used for the retrospective analysis of day 0, 14, and 30 sera obtained from Lewis rat recipients of isogeneic fresh infrarenal aortic grafts (group A) or Brown-Norway rat aortic grafts (group B, C, D) for the presence of donor-specific anti-MHC class I and II antibodies. Tacrolimus indaily dose of 0.2 mg/kg was administered from day 1 to day 30 (group C) or from day 7 to day 30 (group D). Results: Inhibition of fluorescence-labeled anti-BN-MHC class I and MHC class II antibodies binding to BN-splenocytes was observed
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of transplantation
ISSN
1425-9524
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
may
Country of publishing house
PL - POLAND
Number of pages
8
Pages from-to
225-232
UT code for WoS article
000342976000001
EID of the result in the Scopus database
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