Long-term biological variability of galectin-3 after heart transplantation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059169" target="_blank" >RIV/00023001:_____/15:00059169 - isvavai.cz</a>
Result on the web
<a href="http://www.degruyter.com/view/j/cclm.2015.53.issue-1/cclm-2013-1088/cclm-2013-1088.xml" target="_blank" >http://www.degruyter.com/view/j/cclm.2015.53.issue-1/cclm-2013-1088/cclm-2013-1088.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/cclm-2013-1088" target="_blank" >10.1515/cclm-2013-1088</a>

Result language
angličtina
Original language name
Long-term biological variability of galectin-3 after heart transplantation
Original language description
Background: Galectin-3 is an emerging biomarker of heart failure and of myocardial fibrosis risk. Monitoring of galectin-3 is essential during treatment with galectin-3 inhibitors. The aim of our study was to assess long-term biological variability in a specific group of unhealthy subjects. Methods: The biological variability of galectin-3 was measured in a group of 44 patients after heart transplantation (HTx). Six samples were taken from each patient during a 12-month period. Galectin-3 was measured with an Abbott Architect automated immunoassay. Results: Intraindividual (CVi) and interindividual (CVg) variabilities were calculated together with the reference change value (RCV), the log-normal RCV for increase (RCV+), and the log-normal RCV for decrease (RCV-). The CVi, CVg, RCV, RCV+, and RCV-were 28.2%, 35.6%, 78.6%, 116%, and -53.7%, respectively. The index of individuality was 0.79. Conclusions: The concentrations of galectin-3 in patients followed 12 months after HTx fluctuated around the homeostatic point, with CVi of approximately 28%. RCVs of +116% (log-normal increase) and -54% (log-normal decrease) mean that the concentration of galectin-3 would need to approximately double or decrease by half to indicate a new process.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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