The role of timely measurement of galectin-3, NT-proBNP, cystatin C, and hsTnT in predicting prognosis and heart function after heart transplantation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059714" target="_blank" >RIV/00023001:_____/16:00059714 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/16:43910967
Result on the web
<a href="http://www.degruyter.com/view/j/cclm.2016.54.issue-2/cclm-2014-1218/cclm-2014-1218.xml?format=INT" target="_blank" >http://www.degruyter.com/view/j/cclm.2016.54.issue-2/cclm-2014-1218/cclm-2014-1218.xml?format=INT</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/cclm-2014-1218" target="_blank" >10.1515/cclm-2014-1218</a>
Alternative languages
Result language
angličtina
Original language name
The role of timely measurement of galectin-3, NT-proBNP, cystatin C, and hsTnT in predicting prognosis and heart function after heart transplantation
Original language description
Background: Changes of biomarkers measured soon after heart transplantation (HTx) can reflect different processes: cardiomyocyte necrosis (troponins, high-sensitivity cardiac TnT and TnI), heart function (natriuretic peptides, BNP and NT-proBNP), fibrosis (galectin-3 and ST2), and global cardiorenal risk (cystatin C). We assessed the prognostic role of hsTnT, NT-proBNP, galectin-3 and cystatin C during the early post-transplant period. Methods: A total of 121 consecutive post-HTx patients were assessed. The main outcomes were survival, left ventricular ejection fraction (LVEF) and rejection periods. Survival was assessed after intermediate (12 months) and long periods (total follow-up during study, median of survival 763 days, IR 527-1038 days). LVEF was assessed 12 months after HTx. Rejection was evaluated during follow-up. We report biomarker concentrations measured 10 days and 12 months after HTx. Results: Ten days after HTx, cystatin C and hsTnT predicted death both under univariable and multivariable analysis. These two biomarkers along with galectin-3 were increased in patients with decreased LVEF measured 1 year after HTx. NT-proBNP did not show early prognostic power. None of the measured biomarkers predicted rejection, but hsTnT and NT-proBNP were increased significantly 12 months after HTx in patients with at least one rejection. Conclusions: Cystatin C and hsTnT measured 10 days after HTx can provide prognostic information on survival and galectin-3 measured at the same time may display a relationship to heart function assessed 1 year after HTx. Further study should be carried out in a large cohort of patients.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11269" target="_blank" >NT11269: Myocardial Apoptosis at The Patients After Heart Transplantation: Gender Differences</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical chemistry and laboratory medicine
ISSN
1434-6621
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
339-344
UT code for WoS article
000367814600028
EID of the result in the Scopus database
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