Endocrine effects of duodenal-jejunal exclusion in obese patients with type 2 diabetes mellitus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060061" target="_blank" >RIV/00023001:_____/16:00060061 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21230/16:00309240 RIV/00216208:11110/16:10326719 RIV/00023761:_____/16:N0000010 RIV/00064165:_____/16:10326719

Result on the web

<a href="http://joe.endocrinology-journals.org/content/231/1/11.full.pdf+html" target="_blank" >http://joe.endocrinology-journals.org/content/231/1/11.full.pdf+html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1530/JOE-16-0206" target="_blank" >10.1530/JOE-16-0206</a>

Result language

angličtina

Original language name

Endocrine effects of duodenal-jejunal exclusion in obese patients with type 2 diabetes mellitus

Original language description

Duodenal-jejunal bypass liner (DJBL) is an endoscopically implantable device designed to noninvasively mimic the effects of gastrointestinal bypass operations by excluding the duodenum and proximal jejunum from the contact with ingested food. The aim of our study was to assess the influence of DJBL on anthropometric parameters, glucose regulation, metabolic and hormonal profile in obese patients with type 2 diabetes mellitus (T2DM) and to characterize both the magnitude and the possible mechanisms of its effect. Thirty obese patients with poorly controlled T2DM underwent the implantation of DJBL and were assessed before and 1, 6 and 10 months after the implantation, and 3 months after the removal of DJBL. The implantation decreased body weight, and improved lipid levels and glucose regulation along with reduced glycemic variability. Serum concentrations of fibroblast growth factor 19 (FGF19) and bile acids markedly increased together with a tendency to restoration of postprandial peak of GLP1. White blood cell count slightly increased and red blood cell count decreased throughout the DJBL implantation period along with decreased ferritin, iron and vitamin B12 concentrations. Blood count returned to baseline values 3 months after DJBL removal. Decreased body weight and improved glucose control persisted with only slight deterioration 3 months after DJBL removal while the effect on lipids was lost. We conclude that the implantation of DJBL induced a sustained reduction in body weight and improvement in regulation of lipid and glucose. The increase in FGF19 and bile acids levels could be at least partially responsible for these effects.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of endocrinology

ISSN

0022-0795

e-ISSN

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Volume of the periodical

231

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

11-22

UT code for WoS article

000385950400004

EID of the result in the Scopus database

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