The relationship between non-HDL cholesterol and macrophage phenotypes in human adipose tissue
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060092" target="_blank" >RIV/00023001:_____/16:00060092 - isvavai.cz</a>
Result on the web
<a href="http://www.jlr.org/content/57/10/1899" target="_blank" >http://www.jlr.org/content/57/10/1899</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1194/jlr.P068015" target="_blank" >10.1194/jlr.P068015</a>
Alternative languages
Result language
angličtina
Original language name
The relationship between non-HDL cholesterol and macrophage phenotypes in human adipose tissue
Original language description
Data from experimental animal models and in vitro studies suggest that both hyperlipoproteinemia and obesity predispose to development of proinflammatory pathways of macrophages within adipose tissue. The aim of this study was to analyze whether non-HDL cholesterol concentration in healthy living kidney donors (LKDs) is related to the number and phenotype of proinflammatory macrophages in visceral and subcutaneous adipose tissue. Adipose tissue samples were collected by cleansing the kidney grafts of LKDs obtained peroperatively. The stromal vascular fractions of these tissues were analyzed by flow cytometry. Proinflammatory macrophages were defined as CD14(+) cells coexpressing CD16(+) and high-expression CD36 as well (CD14(+) CD16(+) CD36(+++)), while CD16 negativity and CD163 positivity identified alternatively stimulated, anti-inflammatory macrophages. Non-HDL cholesterol concentration positively correlated to proinflammatory macrophages within visceral adipose tissue, with increased strength with more precise phenotype determination. On the contrary, the proportion of alternatively stimulated macrophages correlated negatively with non-HDL cholesterol. The present study suggests a relationship of non-HDL cholesterol concentration to the number and phenotype proportion of macrophages in visceral adipose tissue of healthy humans.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of lipid research
ISSN
0022-2275
e-ISSN
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Volume of the periodical
57
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1899-1905
UT code for WoS article
000387231600015
EID of the result in the Scopus database
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