Human adipose tissue accumulation is associated with pro-inflammatory changes in subcutaneous rather than visceral adipose tissue

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373833" target="_blank" >RIV/00216208:11130/17:10373833 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/17:00075952

Result on the web

<a href="https://doi.org/10.1038/nutd.2017.15" target="_blank" >https://doi.org/10.1038/nutd.2017.15</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nutd.2017.15" target="_blank" >10.1038/nutd.2017.15</a>

Result language

angličtina

Original language name

Human adipose tissue accumulation is associated with pro-inflammatory changes in subcutaneous rather than visceral adipose tissue

Original language description

The importance of the involvement of adipose tissue macrophage subpopulations in obesity-related disorders is well known from different animal models, but human data are scarcer. Subcutaneous (n = 44) and visceral (n = 52) adipose tissues of healthy living kidney donors were obtained during living donor nephrectomy. Stromal vascular fractions were isolated and analysed by flow cytometry using CD14, CD16, CD36 and CD163 antibodies. Total macrophage numbers in subcutaneous adipose tissue increased (P = 0.02) with body mass index (BMI), with a similar increase seen in the proportion of phagocytic CD14+CD16+CD36(high) macrophages (P &lt; 0.01). On the other hand, there was an inverse correlation between anti-inflammatory CD14+CD16 - CD163+ macrophages (P &lt; 0.05) and BMI. These correlations disappeared after excluding obese subjects (BMI &gt;= 30 kg m(-2)) from the analysis. Interestingly, none of these subpopulations were significantly related to BMI in visceral adipose tissue. Obesity per se is associated with distinct, highly phagocytic macrophage accumulation in human subcutaneous adipose tissue.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nutrition &amp; Diabetes [online]

ISSN

2044-4052

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

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UT code for WoS article

000401107800007

EID of the result in the Scopus database

2-s2.0-85017365010