Perfusion scintigraphy in the assessment of autologous cell therapy in diabetic patients with critical limb ischemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077232" target="_blank" >RIV/00023001:_____/18:00077232 - isvavai.cz</a>

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/67/67_583.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/67/67_583.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Perfusion scintigraphy in the assessment of autologous cell therapy in diabetic patients with critical limb ischemia

Original language description

Perfusion scintigraphy with technetium-99-methoxy-isobutyl-isonitrile ((TC)-T-99m-MIBI) is often used for assessing myocardial function but the number of studies concerning lower limb perfusion is limited. The aim of our study was to assess whether (TC)-T-99m-MIBI was an eligible method for evaluation of the effect of cell therapy on critical limb ischemia (CLI) in diabetic patients. (TC)-T-99m-MIBI of calf muscles was performed before and 3 months after autologous cell therapy (ACT) in 24 diabetic patients with CLI. Scintigraphic parameters such as rest count and exercising count after a stress test were defined. These parameters and their ratios were compared between treated and untreated (control) limbs and with changes in transcutaneous oxygen pressure (TcPO2) that served as a reference method. The effect of ACT was confirmed by a significant increase in TcPO2 values (p&lt;0.001) at 3 months after ACT. We did not observe any significant changes of scintigraphic parameters both at rest and after stress 3 months after ACT, there were no differences between treated and control limbs and no association with TcPO2 changes. Results of our study showed no significant contribution of (TC)-T-99m-MIBI of calf muscles to the assessment of ACT in diabetic patients with CLI over a 3-month follow-up period.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV16-27262A" target="_blank" >NV16-27262A: A comparison of the impact of autologous stem cells therapy and standard revascularization on tissue oxygen supply and course of the diabetic foot</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

67

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

583-589

UT code for WoS article

000442016100007

EID of the result in the Scopus database

2-s2.0-85051604121