Difference in serum endostatin levels in diabetic patients with critical limb ischemia treated by autologous cell therapy or percutaneous transluminal angioplasty

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077379" target="_blank" >RIV/00023001:_____/18:00077379 - isvavai.cz</a>

Result on the web

<a href="https://journals.sagepub.com/doi/pdf/10.1177/0963689718775628" target="_blank" >https://journals.sagepub.com/doi/pdf/10.1177/0963689718775628</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0963689718775628" target="_blank" >10.1177/0963689718775628</a>

Result language

angličtina

Original language name

Difference in serum endostatin levels in diabetic patients with critical limb ischemia treated by autologous cell therapy or percutaneous transluminal angioplasty

Original language description

The aim of this study was to compare the serum levels of the anti-angiogenic factor endostatin (S-endostatin) as a potential marker of vasculogenesis after autologous cell therapy (ACT) versus percutaneous transluminal angioplasty (PTA) in diabetic patients with critical limb ischemia (CLI). A total of 25 diabetic patients with CLI treated in our foot clinic during the period 2008-2014 with ACT generating potential vasculogenesis were consecutively included in the study; 14 diabetic patients with CLI who underwent PTA during the same period were included in a control group in which no vasculogenesis had occurred. S-endostatin was measured before revascularization and at 1, 3, and 6 months after the procedure. The effect of ACT and PTA on tissue ischemia was confirmed by transcutaneous oxygen pressure (TcPO2) measurement at the same intervals. While S-endostatin levels increased significantly at 1 and 3 months after ACT (both P &lt; 0.001), no significant change of S-endostatin after PTA was observed. Elevation of S-endostatin levels significantly correlated with an increase in TcPO2 at 1 month after ACT (r = 0.557; P &lt; 0.001). Our study showed that endostatin might be a potential marker of vasculogenesis because of its significant increase after ACT in diabetic patients with CLI in contrast to those undergoing PTA. This increase may be a sign of a protective feedback mechanism of this anti-angiogenic factor.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/NV16-27262A" target="_blank" >NV16-27262A: A comparison of the impact of autologous stem cells therapy and standard revascularization on tissue oxygen supply and course of the diabetic foot</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell transplantation

ISSN

0963-6897

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

1368-1374

UT code for WoS article

000445638100007

EID of the result in the Scopus database

2-s2.0-85051604121