Role of Serum Levels of Angiogenic Cytokines in Assessment of Angiogenesis After Stem Cell Therapy of Diabetic Patients With Critical Limb Ischemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10293639" target="_blank" >RIV/00216208:11110/14:10293639 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/14:00439786 RIV/00023001:_____/14:00059107
Result on the web
<a href="http://dx.doi.org/10.3727/096368913X674071" target="_blank" >http://dx.doi.org/10.3727/096368913X674071</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3727/096368913X674071" target="_blank" >10.3727/096368913X674071</a>
Alternative languages
Result language
angličtina
Original language name
Role of Serum Levels of Angiogenic Cytokines in Assessment of Angiogenesis After Stem Cell Therapy of Diabetic Patients With Critical Limb Ischemia
Original language description
The release of proangiogenic cytokines into the circulation after stem cell (SC) therapy and compensatory increase of angiogenesis inhibitors may reflect local vasculogenesis but also can increase the risk of side effects. The aim of our study was to evaluate serum levels of angiogenic cytokines with regard to the assessment of local and systemic vasculogenesis in diabetic patients with no-option critical limb ischemia (NO-CLI). Twenty-five diabetic patients with NO-CLI I treated with SCs isolated frombone marrow or stimulated peripheral blood were included in the study. Serum levels of proangiogenic cytokines (VEGF, bFGF, Ang-1, PDGF-AA, and PDGF-BB) and an antiangiogenic cytokine (endostatin) were assessed 6 months after cell treatment, compared tobaseline values, and correlated with the number of injected CD34(+) cells. The clinical effect of SC therapy (assessed by changes in TcPO2) and potential systemic vasculogenesis (assessed by eye fundus examination) were evaluated after 6
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Transplantation
ISSN
0963-6897
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1517-1523
UT code for WoS article
000346626300004
EID of the result in the Scopus database
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