Low-molecular-weight paramagnetic F-19 contrast agents for fluorine magnetic resonance imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00077807" target="_blank" >RIV/00023001:_____/19:00077807 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10393766 RIV/00216208:11110/19:10393766 RIV/00216208:11320/19:10393766
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007%2Fs10334-018-0721-9.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007%2Fs10334-018-0721-9.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10334-018-0721-9" target="_blank" >10.1007/s10334-018-0721-9</a>
Alternative languages
Result language
angličtina
Original language name
Low-molecular-weight paramagnetic F-19 contrast agents for fluorine magnetic resonance imaging
Original language description
Objective(19)F MRI requires biocompatible and non-toxic soluble contrast agents with high fluorine content and with suitable F-19 relaxation times. Probes based on a DOTP chelate with 12 magnetically equivalent fluorine atoms (DOTP-tfe) and a lanthanide(III) ion shortening the relaxation times were prepared and tested.MethodsComplexes of DOTP-tfe with trivalent paramagnetic Ce, Dy, Ho, Tm, and Yb ions were synthetized and characterized. F-19 relaxation times were determined and compared to those of the La complex and of the empty ligand. In vitro and in vivo F-19 MRI was performed at 4.7T.Results(19)F relaxation times strongly depended on the chelated lanthanide(III) ion. T-1 ranged from 6.5 to 287ms, T-2 from 3.9 to 124.4ms, and T-2* from 1.1 to 3.1ms. All complexes in combination with optimized sequences provided sufficient signal in vitro under conditions mimicking experiments in vivo (concentrations 1.25mM, 15-min scanning time). As a proof of concept, two contrast agents were injected into the rat muscle; F-19 MRI in vivo confirmed the in vivo applicability of the probe.ConclusionDOTP-based F-19 probes showed suitable properties for in vitro and in vivo visualization and biological applications. The lanthanide(III) ions enabled us to shorten the relaxation times and to trim the probes according to the actual needs. Similar to the clinically approved Gd3+ chelates, this customized probe design ensures consistent biochemical properties and similar safety profiles.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Magnetic resonance materials in physics, biology and medicine
ISSN
0968-5243
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
115-122
UT code for WoS article
000460767000012
EID of the result in the Scopus database
2-s2.0-85057583208